Frailty Trajectories and Their Association With Health Outcomes

Completed

• Conditions: Frailty Syndrome
• Interventions: Other: observation

• Registration Number: NCT05793229
• Lead Sponsor: Nanjing Medical University

Brief Summary

Frailty is common in gastric cancer survivors and seriously affects their prognosis. Multiple longitudinal follow-up assessment of frailty could provide a better understanding of the frailty change of individuals. Our aims were to identify the longitudinal trajectories of frailty and estimate their association with health outcomes in elderly gastric cancer survivors.

Detailed Description

Our study suggested the significant heterogeneity in frailty trajectories among elderly gastric cancer survivors, and that different trajectories had different effects on health outcomes. Our results infer the necessity for prevention strategies in elderly gastric cancer survivors to manage heterogeneous frailty trajectories.

Study Timeline

• Study Start: 2021-03-01
• Primary Completion: 2021-10-01
• Study Completion: 2023-02-01
• Status Verified: 2023-03
• Study First Submitted: 2023-03-19
• Study First Submitted QC: 2023-03-19
• Last Update Submitted: 2023-03-19
• Study First Posted: 2023-03-31
• Last Update Posted: 2023-03-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 381

Inclusion Criteria

• diagnosed with gastric cancer by endoscopy or pathology;
• received radical gastrectomy the first time;
• aged ≥60 years;
• been able to communicate simply in writing and verbal;
• completed the data collection of all follow-up points.

Exclusion Criteria

• received radiotherapy or chemotherapy before surgery;
• had other sites of malignant tumors;
• complicated with severe heart, liver, lung and renal insufficiency;
• had physical disability.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
deteriorating frailty	observation	Class 3
improving frailty	observation	Class 1
maintaining frailty	observation	Class 2

Primary Outcome Measures

Name	Time	Method
quality of life (QOL)	at 1-year after surgery	used EORTC QLQ-STO22 to assess.
total costs	at 1-year after surgery	captured from medical records.
1-year hospital readmissions	at 1-year after surgery	captured from medical records.
disability	at 1-year after surgery	used Elderly Disability Assessment Scale to assess.

Trial Locations

Locations (1)

Xueyi Miao; 🇨🇳 Nanjing, Jiangsu, China