Exploration of Frailty Trajectories and Their Association With Health Outcomes in Elderly Gastric Cancer Survivors Undergoing Radical Gastrectomy: a Prospective Longitudinal Observation Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 381
- 试验地点
- 1
- 主要终点
- quality of life (QOL)
研究概览
简要总结
Frailty is common in gastric cancer survivors and seriously affects their prognosis. Multiple longitudinal follow-up assessment of frailty could provide a better understanding of the frailty change of individuals. Our aims were to identify the longitudinal trajectories of frailty and estimate their association with health outcomes in elderly gastric cancer survivors.
详细描述
Our study suggested the significant heterogeneity in frailty trajectories among elderly gastric cancer survivors, and that different trajectories had different effects on health outcomes. Our results infer the necessity for prevention strategies in elderly gastric cancer survivors to manage heterogeneous frailty trajectories.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosed with gastric cancer by endoscopy or pathology;
- •received radical gastrectomy the first time;
- •aged ≥60 years;
- •been able to communicate simply in writing and verbal;
- •completed the data collection of all follow-up points.
排除标准
- •received radiotherapy or chemotherapy before surgery;
- •had other sites of malignant tumors;
- •complicated with severe heart, liver, lung and renal insufficiency;
- •had physical disability.
结局指标
主要结局
quality of life (QOL)
时间窗: at 1-year after surgery
used EORTC QLQ-STO22 to assess.
total costs
时间窗: at 1-year after surgery
captured from medical records.
1-year hospital readmissions
时间窗: at 1-year after surgery
captured from medical records.
disability
时间窗: at 1-year after surgery
used Elderly Disability Assessment Scale to assess.
次要结局
未报告次要终点
研究者
Xueyi Miao
Principal Investigator
Nanjing Medical University