A comparison of midazolam and dexmedetomidine on postoperative delirium in patients undergoing two-staged bilateral total knee replacement under spinal anesthesia: a cross over study
Not Applicable
- Conditions
- Mental and behavioural disorders
- Registration Number
- KCT0008227
- Lead Sponsor
- Jeonbuk National University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 65
Inclusion Criteria
1) informed consent and voluntary participation
2) aged 65-85 years
3) patients undergoing spinal anesthesia for bilateral staged total knee arthroplasty at one week interval
Exclusion Criteria
1) psychologic disorder including schizophrenia, epilepsy, parkinson's disease and dememtia
2) K-MMSE score < 20
3) severe bradycardia (<45 bpm), sick sinus syndrome, type 2 or 3 degree AV block
4) severe hepatic dysfunction
5) severe renal dysfunction
6) history of recent stroke (within 6 months)
7) alcohol or drug dependency
8) difficulty of conmmunication
9) want general anesthesia
10) ASA PS 4-5
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method incidence of postoperative delirium
- Secondary Outcome Measures
Name Time Method severity of postoperative delirium