Evaluation of the Re-mineralizing Effect of Biomimetic Self-Assembling Peptides in Post Orthodontic White Spot Lesions Compared to Fluoride-Based Delivery Systems
试验速览
- 阶段
- 早期 1 期
- 发起方
- 入组人数
- 32
- 主要终点
- Remineralizing process
研究概览
简要总结
During re-mineralization of white spot lesion, Will biomimetic self-assembling peptides improve the re-mineralizating effect of the post orthodontic white spot lesion compared to fluoride-based delivery systems?
详细描述
Conservative dentistry no longer prefers the "drill and fill" concept and advocates reversal of lesions via remineralization. . Remineralization is the process of restoring minerals - again, in the form of mineral ions - to the hydroxyapatite latticework structure. It is three-dimensional, and the lost ions must be replaced with ions having the exact same shape, size and the same electrical charge as those lost from the lattice.
Fluoride and self-assembling peptides have been used as adjuncts to enhance remineralization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 12 Years 至 22 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with post orthodontic white spot lesion.
- •Patients with good oral hygiene.
- •Patients with good general health.
- •Cooperative patients.
- •Subjects who signed the informed consent.
排除标准
- •Patients with tetracycline pigmentation and dental fluorosis.
- •Enamel cavitation.
- •Disable patient.
- •patient with any systemic disease or severe medical complications.
研究组 & 干预措施
Self Assembling peptide
intervention
干预措施: Self Assembling peptide (Drug)
Self Assembling peptide
intervention
干预措施: remineralizing agent (Drug)
Fluoride
Comparator
干预措施: Self Assembling peptide (Drug)
Fluoride
Comparator
干预措施: remineralizing agent (Drug)
结局指标
主要结局
Remineralizing process
时间窗: 6 months
using DIAGNOpen.
次要结局
- Visual assessment(6 months)
研究者
Raneen Ahmed
assistant lecturer
Cairo University