Examining the Impact of Transcranial Focused Ultrasound (tFUS) on Reward Neural Circuitry

Mary Phillips, MD MD (Cantab)1 site in 1 country5 target enrollmentJune 19, 2023

ConditionsImpulsive Behavior

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Impulsive Behavior
Sponsor: Mary Phillips, MD MD (Cantab)
Enrollment: 5
Locations: 1
Primary Endpoint: Blood oxygen level-dependent (BOLD) signal
Status: Withdrawn
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The investigators aim to examine the immediate effect of transcranial focused ultrasound (tFUS) on brain activity and emotions in healthy adults as a first stage toward understanding the predisposing brain mechanisms of underlying substance use disorders.

Detailed Description

In a small pilot study the investigators propose to demonstrate feasibility of using tFUS to target the ventral striatum (VS) in humans by examining VS target engagement by tFUS in healthy human volunteers using a reward processing task that reliably activates the VS.

Registry

clinicaltrials.gov

Start Date

June 19, 2023

End Date

December 2024

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Mary Phillips, MD MD (Cantab)

Responsible Party

Sponsor Investigator

Principal Investigator

Mary Phillips, MD MD (Cantab)

Professor

University of Pittsburgh

Eligibility Criteria

Inclusion Criteria

•18-35 years of age
•No psychiatric history

Exclusion Criteria

•Not between 18-35 years of age
•Has psychiatric history
•History of head injury, neurological, pervasive developmental disorder (e.g. autism), systemic medical disease and treatment (medical records, participant report)
•Mini-Mental State Examination (MMSE) score (cognitive state) \<24
•Premorbid North American Adult Reading Test (NAART) intelligent quotient (IQ) estimate\<85
•Visual disturbance: \<20/40 Snellen visual acuity
•Left/mixed handedness (Annett criteria)
•History of alcohol/substance use disorder (SUD) (all substances, including nicotine), and/or illicit substance use (except cannabis) over the last 6 months (Structured Clinical Interview for Diagnostic and Statistic Manual of Mental Disorders , 5th Edition (DSM-5) (SCID-5)). Urine tests on scan days will exclude current illicit substance use (except cannabis). Salivary alcohol tests on scan days will exclude intoxicated individuals
•Magnetic resonance imaging (MRI) exclusion: metallic objects, e.g., surgical implants; claustrophobia; positive pregnancy test for females or self-report pregnancy
•Unable to understand English