ongitudinal MRI study to catch EARLY scoliotic changes of the Bone and Intervertebral Disc in younger sisters and daughters of adolescent idiopathic scoliosis patients and in boys and girls of the 22q11.2DS population.
- Conditions
- 10028377curvature of the spinescoliose3D curve of the spine
- Registration Number
- NL-OMON53775
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 120
Cohort 1:
- Female,
- 8, 9 or 10 years old
- An older sibling, twin or parent diagnosed with AIS
- No clinical signs of scoliosis at inclusion (physical examination by forward
bending test and Bunnell Scoliometer assessment with a cut-off value of 7°.
- Written informed consent of parents/legal representatives.
Cohort 2:
- Diagnosed with 22q11.2DS
- Girls: 8, 9 or 10 years old.
- Boys: 9, 10 or 11 years old.
- No clinical signs of scoliosis at inclusion (physical examination by forward
bending test and Bunnell Scoliometer assessment with a cut-off value of 7°.
- Written informed consent of parents/legal representatives.
• Contraindications for MR imaging
• Early-onset scoliosis or other spinal deformities
• Other syndromes or neuromuscular disease associated with scoliosis
• Clinical signs of >1cm leg length discrepancy
• Other diseases or injuries, that are related to abnormal spinal growth,
posture, activity levels, or scoliosis development.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter will be the longitudinal changes in segmental axial<br /><br>rotation on MRI of the thoracolumbar spine in subjects that do and do not<br /><br>develop AIS. </p><br>
- Secondary Outcome Measures
Name Time Method