ncovering the genetic basis of schizophrenia: which genes matter the most?

Completed

Conditions: schizophrenia
10039628

Registration Number: NL-OMON31499

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 260

Inclusion Criteria

age between 18 and 50;specific for schizophrenia patients: DSM-IV diagnosis of schizophrenia

Exclusion Criteria

- Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments)
- Drug or alcohol abuse over a period of six months prior to the experiment
- History of closed- or open-head injury
- History of neurological illness or endocrinological dysfunction
- Claustrophobia
- Major medical history
- Chronic use of medication
- History of epilepsy
- History of epilepsy in first-degree relatives
- Incapability of giving an informed consent
- Symptoms indicative of schizophrenia (healthy controls only)
- Symptoms indicative of schizophrenia in first-degree relatives (healthy controls only)
- pregnancy

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Differences in brain activity as measured with functional MRI between<br /><br>siblings with various allele-variants per candidate- gene<br /><br>- Differences in brain activity as measured with fMRI between siblings with<br /><br>psychotic or schizotypic symptoms compared to siblings without such symptoms<br /><br>- Differences in genetic profile of:<br /><br>o Siblings with psychotic or schizotypic symptoms<br /><br>o Siblings without psychotic or schizotypic symptoms<br /><br>o A matched population of healthy controls</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Brain activity as measured with functional MRI, expressed in percent signal<br /><br>change.<br /><br>Control variables:<br /><br>- behavioural measures, expressed in reaction times (ms) and accuracy<br /><br>- heart rate, expressed in beats per minute (bpm), heart rate<br /><br>variability<br /><br>- respiration, expressed in respiration volume per time</p><br>