Comparison of paracetamol and ketorolac on pain management in patients with opium abuse undergoing cardiac surgery

Not Applicable

Recruiting

Conditions: Coronary artery bypass grafting.
Complications of cardiac and vascular prosthetic devices, implants and grafts

Registration Number: IRCT20150216021098N5

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Adult older than 18 years undergoing off-pupm CABG
ASA class 2 or 3
Non-synthetic opium abuse

Exclusion Criteria

Allergy to either of drugs
Consumption of either drugs in the past 48 hours
Preoperative use of nephrotoxic drugs
Presence of renal insufficiency or plasma creatinine higher than 1.3 mg/dL
History of gastrointestinal disease or bleeding, peptic ulcer, perioperative bleeding
Hepatic insufficiency
Ejection fraction less than 40%
Postoperative need for intraaortic ballon pump
perioperative hemodynamic compromise
Unwanter intraoperative events including arrhythmia or cardiac arrest
refusal to stay in the study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain intensity. Timepoint: every one and four hours in the first and second days, respectively after intervention. Method of measurement: Observation (CPOT0 and questioning (NRS) scores.

Secondary Outcome Measures

Name	Time	Method
Additional analgesic requirement. Timepoint: every one hour on the first day and every 4 hours on the second day. Method of measurement: Recording the amount of administered fentanyl in micro-gram.;Frequency of acute kidney injury. Timepoint: Every day after intervention until discharge from the hospital. Method of measurement: AKIN criteria.;Frequency of gastrointestinal bleeding and discomfort. Timepoint: every day after intervention until discharge from the hospital. Method of measurement: Observation and questioning.