A clinical study to evaluate the effect of Trehalose gel in the tretment of gum diseases

Phase 1/2

Completed

Brief Summary: Background & objectives: Trehalose is a non reducing disaccharide in which two glucose molecules are linked together by a 1, 1-glucosidic linkage. It has been shown that trehalose has suppressive effect on pathological bone resorption and it also inhibits proinflammatory cytokine production induced by a major periodontal pathogen Porphyromonas gingivalis. Hence, in the present study an attempt was made to study clinical effects of trehalose gel in chronic periodontitis subjects.

Materials and methods: Thirty patients with two sites in the bilateral quadrants having probing pocket depths of â‰¥ 5mm were selected. Scaling and root planing was performed followed by assessment of gingival index, probing pocket depth, and relative clinical attachment level at baseline and 3 months. Test site received trehalose gel and control site received placebo gel. All the values were subjected for statistical analysis.

Results: Comparison of gingival index, plaque index, pocket probing depth clinically at baseline and 3 months for test and control sites showed significance improvement but there was no significant difference between two sites (i.e. test site & control site) with this regard.

Conclusion: Trehalose gel does not have considerable advantage over SRP alone as an adjunct to scaling and root planing, in the treatment of chronic periodontitis.

Recruitment & Eligibility

Inclusion Criteria

Patients diagnosed to have chronic periodontitis with probing depths of â‰¥ 5mm on two bilateral or contra lateral sites.
Systemically healthy.

Exclusion Criteria

Patients having systemic diseases Patients who have received any topical or systemic antimicrobial treatment in the past 6 months including the use of mouthwash.
Patients who have had periodontal treatment in the last 6 months.
Pregnant and lactating mothers.

Primary Outcome Measures

Name	Time	Method
decrease in clinical inflammation and probing depth	baseline and 3 months

Secondary Outcome Measures

Name	Time	Method

Locations (1): NARAYANA DENTAL COLLEGE AND HOSPITAL
🇮🇳
Nellore, ANDHRA PRADESH, India
NARAYANA DENTAL COLLEGE AND HOSPITAL
🇮🇳Nellore, ANDHRA PRADESH, India
Dhishann Babu Paturu
Principal investigator
9492906374
drdhishannpaturu@gmail.com