Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus
Overview
- Phase
- Phase 4
- Intervention
- cyclosporine and sodium carboximethycellulose
- Conditions
- Dry Eye Syndromes
- Sponsor
- Universidade Federal do Rio de Janeiro
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Dry eye diagnosis was based on a dry eye questionnaire (OSDI), Shirmer I Test, BUT and 1% rose bengal staining of the ocular surface. The same tests were performed at the end of the treatment to verify the improvement of the subjects.
- Last Updated
- 17 years ago
Overview
Brief Summary
This study evaluates the use of topical cyclosporine 0.05% and sodium carboxymethylcellulose 0.5% for the treatment of dry eye disease in patients infected with the human immunodeficiency virus.
Twenty HIV-positive-patients were selected from the Department of Infectious Diseases of the Federal University of Rio de Janeiro Hospital. Dry eye diagnosis was based on a dry eye questionnaire (Ocular Surface Disease Index - OSDI®), Schirmer I Test, break up time and 1% rose bengal staining of the ocular surface. The patients were divided into two groups with ten patients. Group I received sodium carboxymethylcellulose 0.5% drops and group II received sodium carboxymethylcellulose 0,5% drops and topical cyclosporine 0.05% for six months.
Investigators
Eligibility Criteria
Inclusion Criteria
- •HIV seropositivity
- •Dry eye diagnosis
Exclusion Criteria
- •Hepatitis B infection
- •Hepatitis C infection
- •Menopause
- •Rheumatic diseases
- •Contact lens wear
- •Beta-blocker eye drops
- •Blepharitis
- •Use of medications associated with dry eye (diuretics, antidepressive agents, beta-blockers)
Arms & Interventions
1
Ten HIV-positive-patients with dry eye diagnosis received sodium carboxymethylcellulose 0.5% drops (one drop 4 times per day) and topical cyclosporine 0.05% (one drop twice a day) for six months.
Intervention: cyclosporine and sodium carboximethycellulose
2
Ten HIV-positive-patients with dry eye received sodium carboximethylcelullose 0.5% (1 drop 4 times per day) during six months
Intervention: sodium carboximethycellulose
Outcomes
Primary Outcomes
Dry eye diagnosis was based on a dry eye questionnaire (OSDI), Shirmer I Test, BUT and 1% rose bengal staining of the ocular surface. The same tests were performed at the end of the treatment to verify the improvement of the subjects.
Time Frame: six months