Patient-Specific lung Model development, clinicAl validation and pRedicTion of ventilatory response

Recruiting

• Conditions: J80; Adult respiratory distress syndrome

• Registration Number: DRKS00017151
• Lead Sponsor: Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Acute respiratory distress Syndrome (ARDS) according to the Berlin Definition
Computed tomography images of chest present and not older than 24 hours

Exclusion Criteria

Age < 18 years, pregnancy, cardiac pacemaker or other active implants, burns or thoracic skin lesions, high-grade chronic obstructive pulmonary disease, hemodynamic instability despite adequate fluid resuiscitation

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Accuracy of model-predicted tidal volume and driving pressure (airway plateau pressure - positive end-expiratory airway pressure) after a decremental positive end-expiratory pressure trial

Secondary Outcome Measures

Name	Time	Method
Transpulmonary pressure (actual vs. model-predicted)<br><br>end-expiratory lung volume (actual vs. model-predicted)<br><br>regional ventilation distribution as assessed by EIT (%ventral, %dorsal, %right, %left; actual vs. model-predicted)<br><br>regional diaphragmatic excursion, as assessed by ultrasound (actual versus model-predicted)<br><br>Ratio of arterial partial pressure of oxygen to inspired fraction of oxygen after PEEP-Trial (actual vs. model predicted)<br><br>arterial partial pressure of carbon dioxide (actual versus model predicted)