Rocuronium Dose Finding Study After Single-shot or Steady-state Propofol
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- ED-50 of rocuronium
研究概览
简要总结
This study is designed to determine the effective-doses ED-50 and ED-95 (the doses required for a 50% and 95% twitch inhibition, respectively) of the non-depolarizing muscle relaxant rocuronium after single-shot or steady-state propofol anesthesia in a clinical setting.
详细描述
Neuromuscular blocking agents are worldwide used as a standard component of a modern balanced anesthesia regime. They are administered to facilitate tracheal intubation, reduce laryngeal trauma and optimize surgical conditions. The dose usually recommended to facilitate tracheal intubation approximates at least two times the drug´s effective dose ED-95 (the dose required for a 95% effect) depending on the choice of the neuromuscular blocking agent. This overdose is administered to induce a very deep paralysis with a fast onset of action providing clinically acceptable intubating conditions. Moreover, our clinical experience has shown that the dose-relationship of a neuromuscular blocking agents estimated during steady-state anesthesia does not necessarily correlate with the dose-response curve of the same drug during anesthetic induction. Therefore, a discrepancy between the applied dose and the clinical outcome measure, the intubating conditions, becomes apparent. This might be related to effects of the co-administered anesthetics at the neuromuscular junction. While inhaled anesthetics augment the paralyzing effects of non-depolarizering muscle relaxants in a dose-dependent fashion and depend on the duration of anesthesia, little is known about the interactions of the intravenous anesthetic propofol with the non-depolarizing blocking agent rocuronium. We hypothesize that the intravenous administration of propofol also influences the potency of rocuronium dependant on the duration of its application.
This study, therefore, is designed to determine the dose-response relationship of rocuronium after single-shot or steady-state propofol anesthesia in a clinical setting. The primary endpoints are the ED-50s and ED-95s of rocuronium during anesthetic induction with a single-shot propofol and after 30minutes of steady-state propofol anesthesia. The secondary endpoints are the slopes and the intercepts of the respective dose-response-curves, the onset and duration of muscle paralysis and the recovery from neuromuscular blockade.
Materials & Methods
We will investigate patients scheduled for elective low-risk surgical procedures under general anesthesia. Patients will be allocated to two experimental groups. After neuromuscular monitoring is established under remifentanil infusion, patients of the group "Induction" will receive a single-shot propofol followed by injection of rocuronium and endotracheal intubation. Patients of the group "Maintenance" will be anaesthetized with an induction dose of propofol followed by 30 minutes of total intravenous anesthesia (TIVA: propofol/ remifentanil) before rocuronium is administered. Airway will be managed using a laryngeal mask or tracheal intubation.
During surgery, anesthesia will be maintained with TIVA. Onset and duration of neuromuscular blockade and spontaneous recovery will be monitored with electromyography.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for a low risk-surgical procedure under general anesthesia
- •Patients ASA physical status I-III
- •Patients older than 18years
- •Patients having given informed consent to the study
排除标准
- •Patients who decline to give informed consent to the study
- •Known or suspected allergy towards anesthetics or rocuronium
- •Pregnant and breastfeeding women
- •Known or suspected neuromuscular disease
- •Burn injury prior to the investigation
- •Anatomic and functional malformations with expected difficult intubation
- •Anorexia, Bulimia nervosa, Malnutrition
- •Heart failure
- •Use of drugs that interfere with muscle relaxant
研究组 & 干预措施
Single-shot-Propofol & Remifentanil
Induction group: A single-shot propofol induction dose with remifentanil infusion followed by injection of rocuronium (for doses, please see interventions). Airway: tracheal intubation
干预措施: Single-Shot Propofol (Drug)
Single-shot-Propofol & Remifentanil
Induction group: A single-shot propofol induction dose with remifentanil infusion followed by injection of rocuronium (for doses, please see interventions). Airway: tracheal intubation
干预措施: Rocuronium (0.45mg/kg/body mass) (Drug)
30min infusion Propofol & Remifentanil
Maintenance group: 30min of total intravenous anesthesia (TIVA) with propofol and remifentanil before rocuronium (for doses, please see interventions) is administered. Airway: tracheal intubation/laryngeal mask
干预措施: 30min infusion Propofol (Drug)
Single-shot-Propofol & Remifentanil
Induction group: A single-shot propofol induction dose with remifentanil infusion followed by injection of rocuronium (for doses, please see interventions). Airway: tracheal intubation
干预措施: Rocuronium (0.3mg/kg/body mass) (Drug)
30min infusion Propofol & Remifentanil
Maintenance group: 30min of total intravenous anesthesia (TIVA) with propofol and remifentanil before rocuronium (for doses, please see interventions) is administered. Airway: tracheal intubation/laryngeal mask
干预措施: Rocuronium (0.45mg/kg/body mass) (Drug)
30min infusion Propofol & Remifentanil
Maintenance group: 30min of total intravenous anesthesia (TIVA) with propofol and remifentanil before rocuronium (for doses, please see interventions) is administered. Airway: tracheal intubation/laryngeal mask
干预措施: Rocuronium (0.3mg/kg/body mass) (Drug)
30min infusion Propofol & Remifentanil
Maintenance group: 30min of total intravenous anesthesia (TIVA) with propofol and remifentanil before rocuronium (for doses, please see interventions) is administered. Airway: tracheal intubation/laryngeal mask
干预措施: Rocuronium (0.2mg/kg/body mass) (Drug)
30min infusion Propofol & Remifentanil
Maintenance group: 30min of total intravenous anesthesia (TIVA) with propofol and remifentanil before rocuronium (for doses, please see interventions) is administered. Airway: tracheal intubation/laryngeal mask
干预措施: Rocuronium (0.15mg/kg/body mass) (Drug)
30min infusion Propofol & Remifentanil
Maintenance group: 30min of total intravenous anesthesia (TIVA) with propofol and remifentanil before rocuronium (for doses, please see interventions) is administered. Airway: tracheal intubation/laryngeal mask
干预措施: Rocuronium (0.1mg/kg/body mass) (Drug)
30min infusion Propofol & Remifentanil
Maintenance group: 30min of total intravenous anesthesia (TIVA) with propofol and remifentanil before rocuronium (for doses, please see interventions) is administered. Airway: tracheal intubation/laryngeal mask
干预措施: Rocuronium (0.07mg/kg/body mass) (Drug)
30min infusion Propofol & Remifentanil
Maintenance group: 30min of total intravenous anesthesia (TIVA) with propofol and remifentanil before rocuronium (for doses, please see interventions) is administered. Airway: tracheal intubation/laryngeal mask
干预措施: Remifentanil infusion (Drug)
Single-shot-Propofol & Remifentanil
Induction group: A single-shot propofol induction dose with remifentanil infusion followed by injection of rocuronium (for doses, please see interventions). Airway: tracheal intubation
干预措施: Rocuronium (0.2mg/kg/body mass) (Drug)
Single-shot-Propofol & Remifentanil
Induction group: A single-shot propofol induction dose with remifentanil infusion followed by injection of rocuronium (for doses, please see interventions). Airway: tracheal intubation
干预措施: Rocuronium (0.15mg/kg/body mass) (Drug)
Single-shot-Propofol & Remifentanil
Induction group: A single-shot propofol induction dose with remifentanil infusion followed by injection of rocuronium (for doses, please see interventions). Airway: tracheal intubation
干预措施: Rocuronium (0.1mg/kg/body mass) (Drug)
Single-shot-Propofol & Remifentanil
Induction group: A single-shot propofol induction dose with remifentanil infusion followed by injection of rocuronium (for doses, please see interventions). Airway: tracheal intubation
干预措施: Rocuronium (0.07mg/kg/body mass) (Drug)
Single-shot-Propofol & Remifentanil
Induction group: A single-shot propofol induction dose with remifentanil infusion followed by injection of rocuronium (for doses, please see interventions). Airway: tracheal intubation
干预措施: Remifentanil infusion (Drug)
结局指标
主要结局
ED-50 of rocuronium
时间窗: Anesthesia time during their surgical procedure (=arrival in the OR until discharge from the post-anesthesia care unit), ca. 180min
The primary outcome measure is the 1) ED-50 of rocuronium during anesthesia induction with propofol and after steady-state propofol anesthesia
ED-95 of rocuronium
时间窗: Anesthesia time during their surgical procedure (=arrival in the OR until discharge from the post-anesthesia care unit), ca. 180min
The primary outcome measure is 2) the ED-95 of rocuronium during anesthesia induction with propofol and after steady-state propofol anesthesia
次要结局
- Pharmacodynamics of rocuronium (composite outcome measure)(Anesthesia time during their surgical procedure (=arrival in the OR until discharge from the post-anesthesia care unit), ca. 180min)