NCT00002039已完成不适用
An Open Study of Foscarnet Treatment First Episode CMV-Retinitis in AIDS Patients
Astra USA2 个研究点 分布在 1 个国家开始时间: 2001年8月31日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 试验地点
- 2
研究概览
简要总结
To evaluate the safety and efficacy of foscarnet induction therapy for treatment of AIDS patients experiencing their first episode of cytomegalovirus (CMV) retinitis. To evaluate the safety and efficacy of three different foscarnet maintenance therapy regimens. To determine the pharmacokinetics of intermittent administration of foscarnet with or without concomitant administration of zidovudine (AZT).
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Exclusion Criteria
- •Co-existing Condition:
- •Patients with the following are excluded:
- •Any clinically significant pulmonary or neurologic impairment (e.g., patients who are intubated or comatose).
- •Corneal, lens, or vitreous opacification which precludes examination of the fundi, or evidence of tuberculotic, diabetic and/or hypertensive retinopathy.
- •Known allergy to foscarnet.
- •Recurrent episode of cytomegalovirus (CMV) retinitis.
- •Concurrent Medication:
- •Nephrotoxic drugs.
- •Patients with the following are excluded:
- •Recurrent episode of cytomegalovirus (CMV) retinitis.
- •Any clinically significant pulmonary or neurologic impairment (e.g., patients who are intubated or comatose).
- •Corneal, lens, or vitreous opacification which precludes examination of the fundi, or evidence of tuberculotic, diabetic, and/or hypertensive retinopathy.
- •Known allergy to foscarnet.
- •Prior Medication:
- •Ganciclovir for cytomegalovirus (CMV) retinitis.
- •Foscarnet for CMV retinitis.
- •Patients with AIDS as defined by the CDC with manifest first episode cytomegalovirus (CMV) retinitis, as identified by its characteristic ophthalmoscopic appearance and verified by fundus photography.
- •Patients must be able to give informed consent.
排除标准
- 未提供
研究者
研究点 (2)
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