Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis

Not Applicable

Withdrawn

• Conditions: Pulse Wave; Aortic Stenosis
• Interventions: Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction; Other: Control group without heart disease

• Registration Number: NCT03140735
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Aortic valve pathology is the third most common cardiovascular disease after coronary artery disease and hypertension, which is responsible for severe morbidity and mortality in elderly patients and requires surgical treatment in its most severe form of progression. The purpose of this study is to find a link between arterial stiffness and degenerative aortic stenosis. If this link is established, arterial stiffness may become a medical therapeutic target in order to delay the evolution of the disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-04-14
• Study First Submitted QC: 2017-05-02
• Study First Posted: 2017-05-04
• Study Start: 2017-07-03
• Primary Completion: 2023-06-20
• Study Completion: 2023-06-20
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-18
• Last Update Posted: 2023-07-20

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patients over 18 years of age, without legal protection (guardianship or curatorship),
• Stable hemodynamic status.
• Affiliation to a social security scheme

Exclusion Criteria

• Hemodynamically unstable patients: Systolic PA <10 cmHg, rapid peripheral pulse and spinning, mottling, obnubilation, oliguria, sweating, coma
• History of significant valvulopathy other than an aortic stenosis,
• Pregnancy.
• Patient under tutelage or curatelle or deprived of public right.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients with Serious Aortic Retention	Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction	-
Patients with aortic sclerosis	Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction	-
Control group of 150 heart disease-free individuals	Control group without heart disease	-
Patients with moderate aortic stenting (RA)	Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction	-

Primary Outcome Measures

Name	Time	Method
Analysis of echocardiographic measurements of possible differences between average VOP and Sao i in terms of RA severities	10 years	Analysis of echocardiographic measurements of possible differences between average VOP and Sao i in terms of RA severities

Trial Locations

Locations (1)

CHU Amiens Picardie; 🇫🇷 Amiens, Picardie, France