Association Between Hidradenitis Suppurativa and Spondyloarthritis

Not Applicable

Completed

• Conditions: Hidradenitis Suppurativa
• Interventions: Radiation: magnetic resonance imaging (MRI) of the sacro-iliac region HLA B27 test C-reactive protein (CRP) measurement

• Registration Number: NCT03668925
• Lead Sponsor: CHU de Reims

Brief Summary

Hidradenitis suppurativa is a chronic dermatosis, characterized by an inflammation of the follicular epithelium in the apocrine glands.

The hypothesis of a link between hidradenitis suppurativa and inflammatory rheumatism has been widely considered, with evidence in support of this theory accumulating from several case reports and small series. The most frequently cited rheumatismal disease thought to be associated with Hidradenitis suppurativa is spondyloarthritis.

Taken together, these data suggest that there may a link between hidradenitis suppurativa and spondyloarthritis, but literature data are sparse, and to date, no study has investigated or demonstrated such a relation. Indeed, existing studies to date were observational, descriptive, and retrospective, and did not use modern diagnostic approaches for documenting spondyloarthritis, such as magnetic resonance imaging (MRI) or the recent classification of spondyloarthritis.

Detailed Description

The aim of the study was to test the hypothesis that the risk of spondyloarthritis is increased in patients with hidradenitis suppurativa.

Study Timeline

• Study Start: 2013-05-01
• Primary Completion: 2014-04-01
• Study Completion: 2015-09-01
• Status Verified: 2018-08
• Study First Submitted: 2018-08-07
• Study First Submitted QC: 2018-09-12
• Last Update Submitted: 2018-09-12
• Study First Posted: 2018-09-13
• Last Update Posted: 2018-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• for case: patients with diagnosis of hidrosadenitis suppurativa in the Department of Dermatology of the University Hospital of Reims, regardless of the stage of severity and duration of their disease
• for control: patients without diagnosis of hidrosadenitis suppurativa matched to cases for age (±5 years) and sex
• for case and control: have accepted to take part in the research

Exclusion Criteria

• for case and control: age <18 years old

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group "control"	magnetic resonance imaging (MRI) of the sacro-iliac region HLA B27 test C-reactive protein (CRP) measurement	patient without hidrosadenitis suppurativa
Group "Case"	magnetic resonance imaging (MRI) of the sacro-iliac region HLA B27 test C-reactive protein (CRP) measurement	patient diagnosed with hidrosadenitis suppurativa

Primary Outcome Measures

Name	Time	Method
spondyloarthritis	Day 0	spondyloarthritis was diagnosed by a rheumatologist using the Assessment of SpondyloArthritis international Society (ASAS) criteria

Trial Locations

Locations (1)

Damien JOLLY; 🇫🇷 Reims, France