Association Between Hidradenitis Suppurativa and Spondyloarthritis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- CHU de Reims
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- spondyloarthritis
Study Overview
Brief Summary
Hidradenitis suppurativa is a chronic dermatosis, characterized by an inflammation of the follicular epithelium in the apocrine glands.
The hypothesis of a link between hidradenitis suppurativa and inflammatory rheumatism has been widely considered, with evidence in support of this theory accumulating from several case reports and small series. The most frequently cited rheumatismal disease thought to be associated with Hidradenitis suppurativa is spondyloarthritis.
Taken together, these data suggest that there may a link between hidradenitis suppurativa and spondyloarthritis, but literature data are sparse, and to date, no study has investigated or demonstrated such a relation. Indeed, existing studies to date were observational, descriptive, and retrospective, and did not use modern diagnostic approaches for documenting spondyloarthritis, such as magnetic resonance imaging (MRI) or the recent classification of spondyloarthritis.
Detailed Description
The aim of the study was to test the hypothesis that the risk of spondyloarthritis is increased in patients with hidradenitis suppurativa.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •for case: patients with diagnosis of hidrosadenitis suppurativa in the Department of Dermatology of the University Hospital of Reims, regardless of the stage of severity and duration of their disease
- •for control: patients without diagnosis of hidrosadenitis suppurativa matched to cases for age (±5 years) and sex
- •for case and control: have accepted to take part in the research
Exclusion Criteria
- •for case and control: age <18 years old
Arms & Interventions
Group "Case"
patient diagnosed with hidrosadenitis suppurativa
Intervention: magnetic resonance imaging (MRI) of the sacro-iliac region HLA B27 test C-reactive protein (CRP) measurement (Radiation)
Group "control"
patient without hidrosadenitis suppurativa
Intervention: magnetic resonance imaging (MRI) of the sacro-iliac region HLA B27 test C-reactive protein (CRP) measurement (Radiation)
Outcomes
Primary Outcomes
spondyloarthritis
Time Frame: Day 0
spondyloarthritis was diagnosed by a rheumatologist using the Assessment of SpondyloArthritis international Society (ASAS) criteria
Secondary Outcomes
No secondary outcomes reported