Sudarshan Kriya Yoga and Cardiac Autonomic Control in Patients With Anxiety-Depression Disorders

Not Applicable

Completed

• Conditions: Depression; Anxiety
• Interventions: Other: SKY therapy; Drug: usual drug therapy

• Registration Number: NCT02828072
• Lead Sponsor: University of Milan

Brief Summary

The effects of Sudarshan Kriya Yoga (SKY) on autonomic function in patients with anxiety-depression disorders is unknown. Thus, the authors will investigate cardiac autonomic control in a population of patients with anxiety-depression disorders which will undergo a specific SKY treatment.

Detailed Description

Several studies have demonstrated that adjuvant therapies as exercise and breathing training are effective in improving cardiac autonomic control (CAC) in patients with affective spectrum disorders. However, the effects of Sudarshan Kriya Yoga (SKY) on autonomic function in this population is unknown. To test the hypothesis that SKY training improves CAC, cardiorespiratory coupling and adaptive response of sympatho-vagal balance to orthostatic changes were evaluated in patients with anxiety and/or depression disorders.

The authors will enroll patients with a diagnosis of anxiety and/or depression disorders (DSM-IV) and they will divide them in two groups: 1) conventional therapy (Control) and 2) conventional therapy associated with SKY (Treatment) for 15 days. Anxiety and depression levels will be determined using quantitative questionnaires. For the assessment of CAC and cardiorespiratory coupling, cardiorespiratory traces will be analyzed using monovariate and bivariate autoregressive spectral analysis, respectively.

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2011-09
• Study Completion: 2012-03
• Study First Submitted: 2016-06-30
• Status Verified: 2016-07
• Study First Submitted QC: 2016-07-06
• Last Update Submitted: 2016-07-06
• Study First Posted: 2016-07-11
• Last Update Posted: 2016-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• diagnosis of anxiety-depression disorder

Exclusion Criteria

• absence of sinus rhythm on ECG
• absence of any cardiovascular and metabolic disorder

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sky	SKY therapy	Sky treatment foe 15 days
control	usual drug therapy	standard medical therapy

Primary Outcome Measures

Name	Time	Method
Changes in autonomic control	1 month	Parameter derived from heart rate variability: LF/HF (marker of sympatho-vagal balance)