NCT01436734已完成不适用
Role of Aprotinin in Glucagon Degradation, Measurement by Radioimmunoactive Method (RIA) I125
University Hospital, Gentofte, Copenhagen2 个研究点 分布在 1 个国家目标入组 5 人开始时间: 2011年7月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 5
- 试验地点
- 2
- 主要终点
- Change in plasma glucagon values measured with c-terminal specific "micro-protocol" RIA4305: 350µl of plasma (duplicate sample).
研究概览
简要总结
The aim of the study was to investigate the role of the Trasylol in glucagon prevention in degradation using radioimmunoactive method with I125. Additionally different incubation time was introduced in human plasma samples after oral glucose stimulation, also in fasted and hypoglycemia blood samples from patients' type 2 diabetes. Since, the structure and the techniques for the glucagon measurement are well described nowadays.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Caucasians 18 years or older with Type 2 diabetes (WHO criteria)
排除标准
- •HbA1c >9 %
- •Liver disease (ALAT/ASAT >2 x upper normal limit)
- •Diabetic nephropathy (s-creatinine >130 µM or albuminuria)
- •Proliferative diabetic retinopathy (anamnestic)
- •Severe arteriosclerosis or heart failure (NYHA group III og IV)
- •treatment with medication not applicable to pause for 12 hours
- •pregnancy or lactation
- •Fasting plasma glucose >15 mM on screening day.
结局指标
主要结局
Change in plasma glucagon values measured with c-terminal specific "micro-protocol" RIA4305: 350µl of plasma (duplicate sample).
时间窗: 120 min
次要结局
未报告次要终点
研究者
Mikkel Christensen
MD
University Hospital, Gentofte, Copenhagen
研究点 (2)
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