Comparison of efficacy of clomiphene citrate and tamoxifen for controlled ovarian stimulation in women with unexplained infertility: Randomised Control Trial.

For women with unexplained infertility, COS is done with oral ovulogens , clomiphene citrate and tamoxifen, superiority of one over the other is not yet established. In this study, two oral ovulogens, clomiphene citrate and tamoxifen will be compared for evaluating the efficacy and safety for controlled ovarian stimulation over 3 cycles in women with unexplained infertility. Concealed allocation by placing in sealed envelopes will be done. Each women will be assigned one envelope and would be categorized into group A and B .Group A will receive clomiphene citrate 50mg orally from day 2 to day 6 of menstrual cycle for 3 cycles. If patient does not ovulate in the first cycle then dose will be increased to 100mg in subsequent cycle .Group B will receive tamoxifen 20 mg from day 2 to day 6 for three cycles. If patient does not ovulate in the first cycle then dose will be increased to 40 mg in subsequent cycle. Comparison of mean number of dominant follicles formed during controlled ovulation stimulation among clomiphene citrate and tamoxifen over 3 cycles will be done. Further ,Mean Endometrial thickness, Mean resistivity index and pulsatility index of ovarian and uterine artery, Proportion of women with biochemical pregnancy (urine pregnancy test positive), Proportion of women with clinical pregnancy will be compared over the 3 cycles.