Motivational Interviewing to Address Suicidal Ideation for Veterans at High Risk for Suicide

Not Applicable

Recruiting

• Conditions: Suicide, Attempted; Suicidal Ideation
• Interventions: Other: Enhanced usual care (EUC); Behavioral: Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R)

• Registration Number: NCT05256940
• Lead Sponsor: VA Office of Research and Development

Brief Summary

The purpose of this project is to conduct a randomized control trial with 470 Veterans to examine the impact of a revised version of Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) on risk for suicide attempts and suicidal ideation when compared to high quality usual care.

Detailed Description

Research suggests that treatments to reduce suicidal behavior may need to focus on both the motivation to live and the motivation to die to obtain optimal effects. The PI developed a revised version of Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) to help Veterans resolve ambivalence about living by increasing the motivation to live, that consists of three sessions delivered in-person, virtually, or by telephone. Enhanced usual care (EUC) for high-risk Veterans includes safety plans administered or reviewed by research therapists, care coordination, and access to a 24-hour crisis hotline. In a preliminary randomized controlled trial (RCT) in psychiatrically hospitalized Veterans, MI-SI-R plus EUC was associated with 50% fewer suicide attempts and 41% lower likelihood of suicidal ideation compared to EUC alone. The investigators are proposing an RCT comparing MI-SI-R plus EUC (MI-SI-R+EUC) to EUC alone in a sample of 470 high-risk Veterans with recent suicidal crises from three VHA Medical Centers, with "high-risk" defined as a suicide attempt within a month or suicidal ideation \> 5 on the Beck Scale for Suicidal Ideation. Half (n = 235) will be randomized to MI-SI-R+EUC (three sessions in-person, via Video Connect, or telephone) and the remaining participants (n = 235) will receive EUC alone. All participants will be asked to complete telephone follow-up assessments at 1, 3, 6, and 12-months after randomization. This will allow the investigators to determine the efficacy of MI-SI-R+EUC in reducing risk for suicide attempts (Aim 1) and reducing overall suicidal ideation (Aim 2) when compared to EUC alone.

Study Timeline

• Study First Submitted: 2022-02-16
• Study First Submitted QC: 2022-02-16
• Study First Posted: 2022-02-25
• Study Start: 2022-11-30
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-15
• Last Update Posted: 2025-01-16
• Primary Completion: 2025-11-30
• Study Completion: 2027-06-29

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 470

Inclusion Criteria

• Veteran status,
• admitted to an inpatient unit, referred by a suicide prevention coordinator, or identified as high-risk via data extraction,
• age 18 and over,
• English speaking and reading, and
• ability to understand the study and provide informed consent,
• high-risk status confirmed by suicide attempt within a month on the Columbia- Suicide Severity Rating Scale or a score > 5 on the Scale for Suicidal Ideation

Exclusion Criteria

• current psychosis,
• active mania,
• dementia,
• impaired decision making capacity, and
• institutionalization due to hospitalization in a non-VA facility, jail, or prison.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Enhanced usual care (EUC)	Enhanced usual care (EUC)	Enhanced usual care (EUC) includes safety plans administered or reviewed by research therapists, care coordination, and access to a 24-hour crisis hotline.
Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R)	Enhanced usual care (EUC)	Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) was developed to help Veterans resolve ambivalence about living by increasing the motivation to live, and is delivered in three sessions in person, virtually, or by telephone.
Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R)	Motivational Interviewing to Address Suicidal Ideation- Revised (MI-SI-R)	Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) was developed to help Veterans resolve ambivalence about living by increasing the motivation to live, and is delivered in three sessions in person, virtually, or by telephone.

Primary Outcome Measures

Name	Time	Method
Columbia-Suicide Severity Rating Scale	12-months	The first primary outcome is the presence (vs. absence) of non-fatal suicide attempts as reported on the Columbia-Suicide Severity Rating Scale.
Beck Scale for Suicidal Ideation	12-month	The second primary outcome is suicidal ideation as reported on the Beck Scale for Suicidal Ideation, which has a range from 0-38, with higher scores indicating more severe suicidal ideation.

Trial Locations

Locations (3)

VA Finger Lakes Healthcare System, Canandaigua, NY; 🇺🇸 Canandaigua, New York, United States

VA Portland Health Care System, Portland, OR; 🇺🇸 Portland, Oregon, United States

Ralph H. Johnson VA Medical Center, Charleston, SC; 🇺🇸 Charleston, South Carolina, United States