Agitation in Alzheimer's Disease
- Conditions
- Alzheimer Disease
- Registration Number
- NCT00000179
- Lead Sponsor
- National Institute on Aging (NIA)
- Brief Summary
Agitation affects 70 to 90 percent of patients with AD. Signs of agitation include verbal and physical aggressiveness, irritability, wandering, and restlessness. These behaviors often make caring for patients at home very difficult. Trazodone and haldol are two of the most commonly prescribed drugs for agitation in AD patients. Behavior management, a non drug approach, has been effective in reducing signs of agitation. Researchers have yet to compare the effectiveness of drug versus non drug therapy to treat agitation in AD patients and determine which is the best treatment. The Alzheimer's Disease Cooperative Study, with funding from the National Institute on Aging, is conducting an agitation treatment program at 21 sites in 16 States. This study will assess which of the above treatments is most effective.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
- Memory problem consistent with a probable diagnosis of Alzheimer's disease (AD)
- Agitation symptoms for at least the past 2 weeks
- Patient has caregiver who can participate
- Patient lives in the same household as the caregiver
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (16)
University of Rochester
🇺🇸Rochester, New York, United States
University Hospitals of Cleveland
🇺🇸Cleveland, Ohio, United States
Mount Sinai Medical Center
🇺🇸New York, New York, United States
Emory University
🇺🇸Atlanta, Georgia, United States
University of Massachusetts
🇺🇸Worcester, Massachusetts, United States
New York University Medical Center
🇺🇸New York, New York, United States
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
Oregon Health Sciences University
🇺🇸Portland, Oregon, United States
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
University of South Florida
🇺🇸Tampa, Florida, United States
Southern Illinois University
🇺🇸Springfield, Illinois, United States
University of California, San Diego
🇺🇸San Diego, California, United States
University of Kentucky
🇺🇸Lexington, Kentucky, United States
University of Miami
🇺🇸Miami, Florida, United States
University of California, Los Angeles
🇺🇸Los Angeles, California, United States
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States