Agitation in Alzheimer's Disease

Phase 3

Completed

• Conditions: Alzheimer Disease

• Registration Number: NCT00000179
• Lead Sponsor: National Institute on Aging (NIA)

Brief Summary

Agitation affects 70 to 90 percent of patients with AD. Signs of agitation include verbal and physical aggressiveness, irritability, wandering, and restlessness. These behaviors often make caring for patients at home very difficult. Trazodone and haldol are two of the most commonly prescribed drugs for agitation in AD patients. Behavior management, a non drug approach, has been effective in reducing signs of agitation. Researchers have yet to compare the effectiveness of drug versus non drug therapy to treat agitation in AD patients and determine which is the best treatment. The Alzheimer's Disease Cooperative Study, with funding from the National Institute on Aging, is conducting an agitation treatment program at 21 sites in 16 States. This study will assess which of the above treatments is most effective.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 1999-10-29
• Study First Submitted QC: 1999-10-29
• Study First Posted: 1999-11-01
• Status Verified: 2005-03
• Last Update Submitted: 2005-06-23
• Last Update Posted: 2005-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Memory problem consistent with a probable diagnosis of Alzheimer's disease (AD)
• Agitation symptoms for at least the past 2 weeks
• Patient has caregiver who can participate
• Patient lives in the same household as the caregiver

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Trial Locations

Locations (16)

University of California, Los Angeles; 🇺🇸 Los Angeles, California, United States

University of California, San Diego; 🇺🇸 San Diego, California, United States

University of Miami; 🇺🇸 Miami, Florida, United States

University of South Florida; 🇺🇸 Tampa, Florida, United States

Emory University; 🇺🇸 Atlanta, Georgia, United States

Southern Illinois University; 🇺🇸 Springfield, Illinois, United States

University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States

University of Kentucky; 🇺🇸 Lexington, Kentucky, United States

University of Massachusetts; 🇺🇸 Worcester, Massachusetts, United States

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States

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