Behavioural and Cerebral Haemodynamic Effects of Caffeine Withdrawal and Caffeine Administration Following 2-week Maintenance or Abstinence
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Northumbria University
- Enrollment
- 110
- Locations
- 1
- Primary Endpoint
- Cognitive performance
Study Overview
Brief Summary
The purpose of this study is to determine the effects of 2 weeks caffeine abstinence as compared to 2 weeks caffeine maintenance (300mg per day)on cognition and mood. Cerebral blood flow effects will also be assessed in a subset of participants. The role of caffeine abstinence/maintenance in the acute effects of caffeine will also be explored.
Detailed Description
The current randomised, placebo-controlled, double-blind, parallel groups study aims to explore the behavioural effects of 2-weeks caffeine abstinence as well as establishing the role of abstinence in the effects of caffeine administration by administering caffeine or placebo to those in a state of chronic and acute abstinence. This research also aims to explore, in a subset of participants, the cerebral blood flow effects of caffeine abstinence and caffeine administration using Near Infrared Spectroscopy (NIRS). Cerebral blood flow will be measured both at rest and during performance of cognitive tasks.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Male/Female
- •18 - 40 years
- •Consume ≥ 150 mg caffeine daily
- •No herbal supplements/prescription medications (excl. contraceptive pill)
- •Non smoker
- •Native English speaker
Exclusion Criteria
- •Diagnosis of any significant medical condition or disorder
- •Any known allergy or hypersensitivity to food.
- •BMI >29.9 or <18.5
- •Blood pressure >139/89
Arms & Interventions
Acute withdrawal
Chronic intervention 100 mg caffeine capsules 3 times per day for 14 days. Acute intervention of placebo capsule on day 15.
Intervention: Caffeine and Placebo (Dietary Supplement)
Acute caffeine-independent of withdrawal
Chronic intervention of placebo capsules 3 times per day for 14 days. Acute intervention of 100 mg caffeine capsule on day 15.
Intervention: Placebo and Caffeine (Dietary Supplement)
Chronic abstinence
Chronic intervention of placebo capsules 3 times per day for 14 days. Acute intervention of placebo capsule on day 15.
Intervention: Placebo (Dietary Supplement)
Acute caffeine-in state of withdrawal
Chronic intervention of 100 mg caffeine capsule 3 times per day for 14 days. Acute intervention of 100 mg caffeine capsule on day 15.
Intervention: Caffeine (Dietary Supplement)
Outcomes
Primary Outcomes
Cognitive performance
Time Frame: 2 weeks
Performance is assessed using COMPASS (Computerised Mental Performance Assessment System), which presents a battery of standard cognitive tasks assessing aspects of attention and memory.
Secondary Outcomes
- Mood(2 weeks)
- Cerebral haemodynamic(2 weeks)
- Sleep(2 weeks)
- Caffeine withdrawal(2 weeks)
Investigators
Crystal Haskell
Dr
Northumbria University