A randomised controlled trial aimed at enhancing immunity to influenza in elderly individuals through reversal of immune senescence mediated by herpes virus infection

niversity of Birmingham (UK)0 sites700 target enrollmentAugust 17, 2011

Overview

Phase: Phase 2
Intervention: Not specified
Conditions: Topic: Primary Care Research Network for England, Inflammatory and Immune System
Sponsor: niversity of Birmingham (UK)
Enrollment: 700
Status: Completed
Last Updated: 7 years ago

No summary available.

Registry

who.int

Start Date

August 17, 2011

End Date

January 1, 2014

Last Updated

7 years ago

Study Type

Interventional

Sex

All

Sponsor

niversity of Birmingham (UK)

•1\. Aged 65 years or above (30% 65\-74 yrs old, 70% aged over 75 yrs)
•2\. Cytomegalovirus (CMV) seropositive
•3\. CMV\-specific CD8\+ and CD4\+ T cell response over 0\.5% of T cell pool at randomisation
•4\. Human leuckocyte antigen (HLA) type of HLA\-A1, A2, B7 or B8
•5\. Predicted epidermal growth factor receptor (eGFR) \> 50ml/min
•6\. Liver function tests (LFT) in normal range
•Target Gender: Male \& Female ; Lower Age Limit 65 years

•1\. On the following medication : Steroids, ciclosporin, mycophenolate, probenecid, tacrolimus, theophylline
•2\. Significant chronic illness as assessed by clinical team
•3\. History of cardiovascular event in the last 6 months
•4\. General practitoner (GP) considers inappropriate to take part
•5\. Unable to provide written consent