Department of Orthopedic Oncology, The First Affiliated Hospital of Sun Yat-sen University
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 345
- 试验地点
- 1
- 主要终点
- Local recurrence rate(LRR)
研究概览
简要总结
Retrospective analysis of specific characteristics of complications and long-term oncological and function outcomes in lower-limb osteosarcoma pediatric patients.
详细描述
Clinical and functional outcomes were compared based on age groups, surgical methods, type of prosthesis, and primary tumor location. Patients were divided into the Low-age group (≤10 years old) and the High-age group (>10 years old). Overall Survival rate (OS), Progression-Free Survival rate (PFS), and prosthesis survival rate were assessed using Kaplan-Meier curves, and non-parametric survival analysis (log-rank test) was used for comparison. The incidence of complications, local relapse rate (LRR), metastasis rate, final limb-salvage and amputation rate, and Musculoskeletal Tumor Society (MSTS) score of different independent groups were further evaluated using χ2 test or Fisher's exact test, and t-test was employed to evaluate the measurement data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 4 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed lower limb osteosarcoma patients under the age of 14;
- •Performing tumor resection treatment in our hospital;
- •There is complete clinical registration data available.
排除标准
- •Not undergoing surgical treatment in our hospital;
- •Age older than 14 years old;
- •No available clinical registration data or lost follow-up patients;
- •Non lower limb osteosarcoma patients.
结局指标
主要结局
Local recurrence rate(LRR)
时间窗: 2000-2019
Oncological outcomes
Final limb-salvage and amputation rate
时间窗: 2000-2019
Oncological outcomes
Overall Survival rate (OS)
时间窗: 2000-2019
Oncological outcomes
Progression-Free Survival rate (PFS)
时间窗: 2000-2019
Oncological outcomes
Metastasis rate
时间窗: 2000-2019
Oncological outcomes
Musculoskeletal Tumor Society (MSTS) score
时间窗: 2000-2019
Functional outcomes
Complications
时间窗: 2000-2019
Functional outcomes
Prosthesis survival rate
时间窗: 2000-2019
Functional outcomes
次要结局
未报告次要终点
研究者
Changye Zou
Clinical Professor
First Affiliated Hospital, Sun Yat-Sen University