A randomized controlled trial to assess the effect of dexamethasone on the incidence of the acute phase response following treatment with zoledronic acid
Phase 4
Completed
- Conditions
- OsteoporosisPaget's diseaseMetabolic bone diseaseMusculoskeletal - OsteoporosisMusculoskeletal - Other muscular and skeletal disorders
- Registration Number
- ACTRN12615000794505
- Lead Sponsor
- Bone & Joint Research Group, University of Auckland
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Females or males aged 20 or older.
Prescribed zoledronic acid for the first time for fracture prevention or Paget's disease.
Exclusion Criteria
Prior treatment with zoledronic acid.
History of fever, infection, or influenza-like illness within the past week.
Diabetes mellitus or uncontrolled hypertension (BP >160/90)
Treatment with glucocorticoids within the past week.
History of adverse reaction to glucocorticoids.
Major systemic illness, including malignancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method