Intermittent fasting after ST-elevation myocardial infarction to improve left ventricular functio
Not Applicable
- Conditions
- I21Acute myocardial infarction
- Registration Number
- DRKS00021784
- Lead Sponsor
- niversitätsklinikum Halle (Saale)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
written informed consent
- ST-elevation myocardial infarction (or equivalent)
Exclusion Criteria
- missing informed consent
- participation in other clinical trials
- patients with cardiac devices not approved for MRI scanning
- kidney failure (GFR <30 ml/min)
- claustrophobia
- antidiabetic therapy with sulfonylurea
- pregnancy
- employees of the study center
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eft ventricular myocardial function at four weeks after randomization (evaluated by echocardiography)
- Secondary Outcome Measures
Name Time Method - all-cause hospitalization<br>- hospitalization from cardiovascular cause<br>- all-cause death<br>- death from cardiovascular cause<br>- myocardial infarction<br>- revascularisation<br>- stroke<br>- patient weight<br>- blood pressure<br>- medication<br>- comorbidities<br>- left ventricular function at three and six months after randomization<br>- further characterization of myocardial function evaluated by echocardiography (i.e. Kinetikstörungen, LVEDP, E/e‘)<br>- myocardial scar and edema (evaluated by cardiac MRI)<br>- clinical chemistry and hematology (hGH, adiponectine, NT-proBNP, creatinine, fasting insulin, fasting blood glucose, HbA1c, blood count, IL-1, IL-6, C-reactive protein, homocysteine, cholesterine, LDL, HDL, triglycerides)<br>- Peripheral Blood Mononuclear Cells<br>- DNA-Methylation of circulating cells („epigenetic clock)<br><br>Follow-up: 6 months. Study visits at regular ambulatory visits at 4 weeks, 3 months, and 6 months