The Efficacy of Neuromuscular Electrical Stimulation to Attenuate Muscle Loss
Not Applicable
Completed
- Conditions
- Critical IllnessMuscle DisuseNeuromuscular Electrical Stimulation (NMES)
- Registration Number
- NCT01521637
- Lead Sponsor
- Hasselt University
- Brief Summary
Subjects who are hospitalized in the ICU will be included after 24 hours of intubation during their ICU stay. Twice-daily Neuromuscular Electrical Stimulation (NMES) will be performed on one leg for 2x40 min per day to assess muscle fiber size. The investigators hypothesize an attenuated loss in muscle fiber size.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 15
Inclusion Criteria
- Male
- Age between 18 and 80 years
- Expected sedated time of >24h
Exclusion Criteria
- Spinal Cord Injury
- Arterial operaties on the legs
- Local wounds that prohibit NMES
- Chronic use of corticosteroids
- Intake of certain antithrombotic drugs
- Presence of implantable cardioverter defibrillator and/or pacemaker
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Change in muscle fiber cross sectional area (CSA) 3 hours before and 12 hours after 10 days of twice-daily NMES Muscle fiber cross sectional area (in um2) for type I and II fibers will be analyzed by using immunohistochemistry; the change of muscle fiber CSA over time will be measured
- Secondary Outcome Measures
Name Time Method Change in upper leg circumference 3 hours before and 12 hours after 10 days of twice-daily NMES Upper leg circumgerence will be measured; the change of upper leg circumference over time will be measured
Trial Locations
- Locations (1)
Jessa Hospital
🇧🇪Hasselt, Belgium
Jessa Hospital🇧🇪Hasselt, Belgium