The Efficacy of Neuromuscular Electrical Stimulation to Attenuate Skeletal Muscle Loss in ICU Patients

Hasselt University1 site in 1 country15 target enrollmentJanuary 2012

ConditionsMuscle Disuse Neuromuscular Electrical Stimulation (NMES)Critical Illness

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Muscle Disuse
Sponsor: Hasselt University
Enrollment: 15
Locations: 1
Primary Endpoint: Change in muscle fiber cross sectional area (CSA)
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Subjects who are hospitalized in the ICU will be included after 24 hours of intubation during their ICU stay. Twice-daily Neuromuscular Electrical Stimulation (NMES) will be performed on one leg for 2x40 min per day to assess muscle fiber size. The investigators hypothesize an attenuated loss in muscle fiber size.

Registry

clinicaltrials.gov

Start Date

January 2012

End Date

April 2015

Last Updated

10 years ago

Study Type

Interventional

Study Design

Single Group

Sex

Male

Investigators

Sponsor

Hasselt University

Responsible Party

Principal Investigator

Dominique Hansen

PhD

Hasselt University

Eligibility Criteria

Inclusion Criteria

•Age between 18 and 80 years
•Expected sedated time of \>24h

Exclusion Criteria

•Spinal Cord Injury
•Arterial operaties on the legs
•Local wounds that prohibit NMES
•Chronic use of corticosteroids
•Intake of certain antithrombotic drugs
•Presence of implantable cardioverter defibrillator and/or pacemaker

Outcomes

Primary Outcomes

Change in muscle fiber cross sectional area (CSA)

Time Frame: 3 hours before and 12 hours after 10 days of twice-daily NMES

Muscle fiber cross sectional area (in um2) for type I and II fibers will be analyzed by using immunohistochemistry; the change of muscle fiber CSA over time will be measured