Reappraisal of Atrial Fibrillation: Interaction between HyperCoagulability, Electrical Remodeling, and Vascular Destabilisation in the Progression of AF (RACE V) - Workpackage 5

Recruiting

• Conditions: atrial fibrillation; 10007521

• Registration Number: NL-OMON53124
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 380

Inclusion Criteria

- Age > 18 years;
- Undergoing first elective open chest cardiac surgery;
- Able and willing to sign informed consent for the registry;
- Able and willing to undergo heart rhythm monitoring with noninvasive
recorders.

Exclusion Criteria

- Deemed unsuitable or not willing to undergo heart rhythm monitoring with
noninvasive recorders or to attend follow-up visits;
- Pregnancy;
- Life expectancy of less than 2.5 years;
- History of prior cardiac surgery or ablation for AF.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Determining genetic, electrical, biochemical, molecular and structural factors<br /><br>in atrial and ventricular biopsies and blood that contribute to AF initiation<br /><br>and progression during 3 years after open heart surgery.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- AF incidence and duration,<br /><br>- severe cardiovascular and cerebral consequences of AF,<br /><br>- complexity of AF on digital EKG,<br /><br>- AF biomarkers associated with AF progression,<br /><br>- CT and ultrasound parameters predictive of AF progression and duration,<br /><br>- genotyping of different AF types.</p><br>