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Clinical Trials/NCT01666821
NCT01666821CompletedNot Applicable

A Population-based Study of Macular Choroidal Neovascularization Using Optical Coherence Tomography in a Chinese Population

Shanghai University of Traditional Chinese Medicine1 site in 1 country59 target enrollmentStarted: May 2004Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
59
Locations
1
Primary Endpoint
change of the early and intermediate-stage AMD

Study Overview

Brief Summary

To investigate pathomorphological and functional variations of choroidal neovascularization (CNV) in age-related macular degeneration (AMD) in a Chinese population using optical coherence tomography (OCT) to find which kinds of Fundus characteristics indicated exudative AMD.

Detailed Description

This population-based study enrolled 59 patients (>45 years old; 70 eyes) with early and intermediate-stage AMD from Youyi Street, Baoshan District, Shanghai, China. Comprehensive standardized ophthalmic examinations included visual acuity, anterior segment analysis by slit lamp, dilated fundus evaluation by direct ophthalmoscopy, 90D handheld lens, fundus photography, fluorescein angiography (FFA), and fast optic disk scans using OCT. The macular CNV characteristic profiles in early and intermediate-stage AMD were determined by OCT. Data were obtained at first visit and 6 to 24 months follow-up, and FFA and OCT outcomes of early and intermediate-stage AMD patients were analyzed.

Study Design

Study Type
Observational
Observational Model
Ecologic Or Community
Time Perspective
Prospective

Eligibility Criteria

Ages
45 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • adults citizens aged above 45 years

Exclusion Criteria

  • lost samples

Outcomes

Primary Outcomes

change of the early and intermediate-stage AMD

Time Frame: May 2004-September 2008

Drusen with unclear boundaries and obvious pigment proliferation, with hypofluorescence around drusens seen on FFA and a slight small arch field located in the retinal pigment epithelium (RPE)/choriocapillary layer (CCL) on OCT indicated exudative AMD.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Shanghai University of Traditional Chinese Medicine
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Jun Hu

Department of ophthalmology, Shuguang hospital(Baoshan branch),Shanghai University of TCM

Shanghai University of Traditional Chinese Medicine

Study Sites (1)

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