Magnetoencephalography by Optical Pumping Magnetometer

Not Applicable

Recruiting

• Conditions: Magnetoencephalography; Neonate; Premature; Optical Pump Magnetometer
• Interventions: Other: Magnetoencephalography

• Registration Number: NCT05835817
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

MagnetoEncephaloGraphy (MEG) is a method of recording brain activity with high temporal resolution and good spatial resolution, compared to current recording techniques such as ElectroEncephaloGraphy (EEG). The main limitation of MEG is its cost due to the sensors used, the Super Quantum Interference Devices (SQUID). These require a complex infrastructure from an instrumentation point of view to operate, requiring liquid helium, most often at a loss, at increasing cost. Optical Pumping Magnetometers (OPM) type sensors represent a promising alternative to SQUIDs sensors, especially since they do not require helium cooling.

The purpose of this project is to Identify biomarkers in Magnetoencephalography of normal brain development in healthy adults, premature and term newborns from "a priori" obtained by the classical technique of High Resolution EEG performed.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-04-11
• Study First Submitted: 2023-04-13
• Study First Submitted QC: 2023-04-26
• Study First Posted: 2023-04-28
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-22
• Last Update Posted: 2025-05-28
• Primary Completion: 2026-04
• Study Completion: 2026-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• For healthy adult volunteers
• Age between 18 and 65
• No pathology, no treatment
• No toxicant intake
• For term newborns
• Child between 38 and 42 weeks gestational age on the day of registration
• No pathology, no treatment
• For children born prematurely
• Child between 28 and 36 weeks gestational age on the day of registration
• No pathology, no treatment apart from routine care related to prematurity
• For pregnant women
• Pregnant with between 28 to 40 weeks gestational age on the day of registration
• No pathology, no treatment

Exclusion Criteria

• Subject and Patients "not compatible" MEG. Wearers of prosthesis or pacemaker likely to generate artefacts interfering with the measurement. There is no danger to the subject, but the measurement itself may be impossible.
• Patients who cannot stand to stand still for a few minutes.
• Newborn on ventilatory assistance or infusion
• Newborn baby not meeting the age criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
full term neonates	Magnetoencephalography	-
premature neonates	Magnetoencephalography	-
pregnant women	Magnetoencephalography	-
Adults	Magnetoencephalography	-

Primary Outcome Measures

Name	Time	Method
Signal to noise ratio of the MEG OPM	1 day	Signal to noise ratio of the MEG OPM is in dB
Signal to noise ratio of HR EEG	1 day	Signal to noise ratio of HR EEG is in dB
Number of dB between Signal to noise ratio of the MEG OPM and Signal to noise ratio of HR EEG	1 day

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France