Eurotransplant Senior (old-for-old) DR-Compatible Program

Recruiting

• Conditions: IERENTRANSPLANTATION; Z94.0; Kidney transplant status

• Registration Number: DRKS00005098
• Lead Sponsor: eiden University Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

1. men or women aged at least 65 years, placed on eurotransplant kidney waiting list with an active urgency;
2. recipients of a first kidney;
3. highest (historic or current) panel reactive antibody (PRA) titers of 5%;
4. negative cross-matches and (if applicable) unacceptable antigens are excluded.

Exclusion Criteria

1. active systemic infection;
2. HIV (antigen or antibody), hepatitis-B (HBsAg), or hepatitis-C (antibody) positivity;
3. history of malignancy within 5 years of enrolment (with the exception of adequately treated non-melanoma skin cancer);
4. known to be poorly compliant with clinic visits or prescribed medication;
5. medical history that might limit the individual's ability to take the defined immunosuppressive agents.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Validation of donor kidney allocation due to assessment of acute rejection 6 month post-transplantation.

Secondary Outcome Measures

Name	Time	Method
Impact on graft function and patient and (death-censored) graft survival up to 5 years.