The Effect of Prolonged Glucagon-like Peptide 1 Infusion on Gastric Emptying in Healthy Volunteers

Phase 2

Recruiting

• Conditions: Hyperglycaemia; Diabetes; Critical Illness Induced Hyperglycaemia; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12612001035819
• Lead Sponsor: Mahesh Umapathysivam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-09-26
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1.Healthy
2.Normal gastric functioning

Exclusion Criteria

- Inability to give informed consent,
- Radiation exposure for research purposes in the past 12 months,
- The ARPANSA guidelines published by the Australian Government entitled Code of Practice Exposure of Humans to Ionizing Radiation for Research Purposes States that the dose constraints for a research participant is 5mSv per year and 10mSv for a 5 year period.
- History of diabetes,
- HbA1c >6.0,
- Taking medication that are known to effect gastrointestinal motility,
- Taking medication effecting blood glucose,
- Creatinine Clearance <100 ml/min (men), 90 ml/min (women)
- Pregnancy,
- Ferritin level < 20microg/L
- Previous surgery on the small intestine,
- Smoking >10 cigarettes per day
- Alcohol >20g per day
- Because of concerns of cumulative life time exposure to radiation, we will directly screen all volunteers as to their previous radiation exposure, and will exclude any volunteer who has received 3 or more examinations using a computerized tomogram and/or 10 or more examinations using standard x-rays.

Study & Design

• Study Type: Interventional
• Study Design: Not specified