Optimization of clinical regimen of traditional Chinese medicine therapy for Parkinson's disease based on AMPK/SIRT3/GSK3ß /LC3 signaling pathway

Phase 1

Recruiting

• Conditions: Parkinson's disease

• Registration Number: ITMCTR1900002787
• Lead Sponsor: The First Affiliated Hospital of Henan University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Early stage:
(1) qualified for TCM diagnostic criteria of fibrillation syndrome;
(2) meet the western diagnostic criteria for Parkinson's disease;
(3) aged >= 50 years, <= 75 years;
(4) the improved Hoehn&Yahr is graded from grade 1 to grade 1.5;
(5) TCM syndrome differentiation: Yin deficiency of liver and kidney.
Middle stage:
(1) qualified for TCM diagnostic criteria of fibrillation syndrome;
(2) meet the western diagnostic criteria for Parkinson's disease;
(3) aged >= 50 years, <= 75 years;
(4) the improved Hoehn & Yahr is graded at level 2 ~ 3;
(5) TCM syndrome differentiation: Yin deficiency of liver and kidney.

Exclusion Criteria

1. Those who have been treated with levodopa or traditional Chinese medicine for tonifying liver and kidney without drug elution;
2. Have serious heart, liver, kidney disease or multiple organ failure, mental illness;
3. A history of drug or alcohol abuse;
4. Pregnant and lactating women;
5. Patients in other studies.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
liver function;Urine routine;Routine blood test;renal function;

Secondary Outcome Measures

Name	Time	Method
electrocardiogram;Routine;