Aerobic Exercise Combined With Blood Flow Restriction Improves Muscle Strength and Functional Capacity In Patients With Emphysematous COPD: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- muscle strength
研究概览
简要总结
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD). The study aimed to determine whether adding BFR to aerobic exercise could enhance muscle strength and functional capacity compared with conventional training alone. The findings demonstrated that aerobic exercise combined with BFR significantly improved lower-limb muscle strength, exercise tolerance, and functional performance in patients with emphysematous COPD. These results suggest that BFR-assisted aerobic training may serve as an effective and safe rehabilitation strategy to improve physical function and quality of life in this population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with emphysematous chronic obstructive pulmonary disease (COPD).
- •Clinically stable COPD patients with no acute exacerbation within the previous 4-6 weeks.
- •Mild to moderate disease severity according to GOLD criteria.
- •Ability to participate safely in aerobic exercise training.
- •Medically stable and cleared by a physician for pulmonary rehabilitation.
- •Ability to understand and follow study instructions.
排除标准
- •Acute COPD exacerbation or respiratory infection during the study period.
- •Severe cardiovascular diseases (e.g., unstable angina, uncontrolled hypertension, recent myocardial infarction).
- •Peripheral vascular disease or contraindications to blood flow restriction (BFR) training.
- •Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise performance.
- •Cognitive impairment affecting cooperation or informed consent.
- •Participation in another structured rehabilitation program during the study period.
- •Severe hypoxemia requiring continuous oxygen therapy during exercise.
- •History of deep vein thrombosis or clotting disorders.
研究组 & 干预措施
experimental group
aerobic exercise with blood flow restriction (BFR) training Procedure: Aerobic Exercise Training Device: Blood Flow Restriction Cuff
干预措施: Aerobic Exercise Combined with Blood Flow Restriction (Other)
control group
aerobic exercise
干预措施: Aerobic exercise (Other)
结局指标
主要结局
muscle strength
时间窗: 8 weeks
quadriceps strength by isokinetic: Quadriceps strength will be measured using an isokinetic dynamometer at an angular velocity of 60°/s. Participants will perform three to five maximal concentric knee extension efforts after familiarization. Peak torque (Nm) will be recorded, and the highest value will be used for statistical analysis
次要结局
- function capacity(8 weeks)
研究者
Hanan Hosny M Battesha
associate professor hanan hosny M Battesha
Al-Zaytoonah University of Jordan