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Multimodal Assessment of Liver Volume and Function

Completed
Conditions
Liver Metastases
Colorectal Cancer
Registration Number
NCT03140917
Lead Sponsor
Karolinska University Hospital
Brief Summary

In liver surgery peroperative assessment och the future liver remnant (FLR) is pivotal in order to avoid posthepatectomy liver failure. To date this is mainly performed by measuring the volume of the FLR. Of course FLR volume acts as a surrogate measure of FLR function and the correlation between volume and function is not always accurate. Several techniques to assess FLR function has been proposed. Hepatobiliary scintigraphy (HBS) and Dynamic MRI are the two such methods. In this study we compare HBS and MRI, in addition to contrast-enhanced CT and ICG, repeatedly performed before and after right hepatectomy in patients with colorectal liver metastases treated with neoadjuvant chemotherapy.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
10
Inclusion Criteria
  • CRLM treated with neoadjuvant chemotherapy subjected to right hepatectomy
Exclusion Criteria

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Correlation between HBS and MRI in assessment of FLR function preopPreop

HBS, MRI, CT and ICG performed the day before surgery

Secondary Outcome Measures
NameTimeMethod
Correlation between HBS and MRI in assessment of FLR function POD 7POD 7

HBS, MRI, CT and ICG performed 7 days after surgery

Correlation between HBS and MRI in assessment of FLR function POD 28POD 28

HBS, MRI, CT and ICG performed 28 days after surgery

Trial Locations

Locations (1)

Karolinska University Hospital

🇸🇪

Stockholm, Sweden

Karolinska University Hospital
🇸🇪Stockholm, Sweden
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