Multimodal Assessment of Liver Volume and Function
- Conditions
- Liver MetastasesColorectal Cancer
- Registration Number
- NCT03140917
- Lead Sponsor
- Karolinska University Hospital
- Brief Summary
In liver surgery peroperative assessment och the future liver remnant (FLR) is pivotal in order to avoid posthepatectomy liver failure. To date this is mainly performed by measuring the volume of the FLR. Of course FLR volume acts as a surrogate measure of FLR function and the correlation between volume and function is not always accurate. Several techniques to assess FLR function has been proposed. Hepatobiliary scintigraphy (HBS) and Dynamic MRI are the two such methods. In this study we compare HBS and MRI, in addition to contrast-enhanced CT and ICG, repeatedly performed before and after right hepatectomy in patients with colorectal liver metastases treated with neoadjuvant chemotherapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- CRLM treated with neoadjuvant chemotherapy subjected to right hepatectomy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation between HBS and MRI in assessment of FLR function preop Preop HBS, MRI, CT and ICG performed the day before surgery
- Secondary Outcome Measures
Name Time Method Correlation between HBS and MRI in assessment of FLR function POD 7 POD 7 HBS, MRI, CT and ICG performed 7 days after surgery
Correlation between HBS and MRI in assessment of FLR function POD 28 POD 28 HBS, MRI, CT and ICG performed 28 days after surgery
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Trial Locations
- Locations (1)
Karolinska University Hospital
🇸🇪Stockholm, Sweden
Karolinska University Hospital🇸🇪Stockholm, Sweden