A Randomized Controlled Trial on the effects of midazolam on the quality of postoperative recovery in patients
Phase 4
Completed
- Conditions
- Anesthesiologischanxiety
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 192
Inclusion Criteria
All patients operated with a laparotomy in Erasmus MC Rotterdam with a planned postoperative stay for min. 3 days in the hospital
Exclusion Criteria
pregnant, benzodiazepine usage, contra-indication for midazolam, mental retardation, non-dutch speeking patients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Quality of postoperative recovery (QoR)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Anxiety<br /><br>Agression<br /><br>Fatique<br /><br>Medical fysiological data<br /><br>Depression<br /><br>Knowledge on the surgery performed<br /><br>Somatic symptoms<br /><br>General Self-Efficacy Scale<br /><br>Self-Esteem</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie midazolam's effects on postoperative recovery and anxiety reduction via GABA-A receptor modulation?
How does midazolam compare to standard-of-care anxiolytics like lorazepam in improving postoperative recovery quality and anxiety management?
Which biomarkers, such as GABA receptor subtypes or anxiety-related genes, predict response to midazolam in phase IV postoperative recovery trials?
What are the potential adverse events of midazolam in phase IV postoperative recovery studies, and how are they managed in clinical practice?
Are there combination therapies involving midazolam and other anesthetic agents that enhance postoperative recovery outcomes compared to monotherapy?