effect of increase in BP on brain energy metabolism

Not yet recruiting

• Conditions: Head Injury

• Registration Number: CTRI/2017/08/009209
• Lead Sponsor: All India Institute of Medical Sciences

Brief Summary

It is prospective, single arm interventional study, to be done in patients with severe head injury undergoing decompressive craniectomy. Cerebral microdialysis is a technique in which biomarkers of ischemia can be detected well before the clinical signs of neurological injury are detected. In this way cerebral microdialysis is proposed to offer a window period to treat ischemia well before its overt manifestation. We plan to conduct this study in which microdialysis catheter will be inserted in brain parenchyma at the time of surgery. This microdialysis cathere will help to analyse brain biochemistry in postoperative period. In patients developing ischemia (as seen by elevation in brain biomarkers of cerebral microdialysis)  following operation, the cerebarl perfusion pressure will be increased by 20% with the help of noradrenaline infusion. Augmentation in cerebral perfusion pressure should improve brain ischemia and thus normalise the brain biochemical markers of ischemia as studied by cerebral microdialysis.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2017-01-08
• Study Start: 2017-08-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

20 adult patients of either gender, undergoing decompressive craniotomy following traumatic brain injury will be enrolled, over a period of 6 months.

Exclusion Criteria

patients where microdialysis catheter cannot be placed or those with Glasgow coma score of 3 on admission, age less than 18 years, pregnant females and associated severe polytrauma.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
•To see the effect of CPP augmentation on ischemia biomarkers (LP Ratio) and intracranial pressure	Every one hour till 48 hours

Secondary Outcome Measures

Name	Time	Method
•To see the correlation between CPP, ICP, ischemia biomarkers on outcome in these patients.	•To see the time interval between increase in ischemia biomarkers and clinical worsening (neurological status, rise in ICP)

Trial Locations

Locations (1)

Jai Prakash Narain Apex Trauma Centre, AIIMS; 🇮🇳 South, DELHI, India

Jai Prakash Narain Apex Trauma Centre, AIIMS

🇮🇳South, DELHI, India

Dr Ashish Bindra

Principal investigator

98698398607

dr_ashi2208@yahoo.com