Effect of supplementation vitamin D in treatment of maintenance methadone treatment patients
Phase 3
- Conditions
- Addiction.????? ????????? ?? ??????
- Registration Number
- IRCT2017042433551N1
- Lead Sponsor
- Vice chancellor for research, Kashan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Patients under methadone maintenance treatment
Aged 18 to 60
Exclusion Criteria
Using colecalciferol 3 months before the intervention
History of metabolic diseases, including diabetes, cardiovascular disease and hypertension before the intervention
Unwillingness to cooperate.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expressed levels of TNF-a gene. Timepoint: At the beginning of the study and 12 weeks after intervention. Method of measurement: PCR.;Expressed levels of LL-1 gene. Timepoint: At the beginning of the study and 12 weeks after intervention. Method of measurement: PCR.;Expressed levels of LL-8 gene. Timepoint: At the beginning of the study and 12 weeks after intervention. Method of measurement: PCR.
- Secondary Outcome Measures
Name Time Method Expressed levels of GAPDH. Timepoint: At the beginning of the study and 12 weeks after intervention. Method of measurement: PCR.;Expressed levels of PPAR-?. Timepoint: At the beginning of the study and 12 weeks after intervention. Method of measurement: PCR.;Withdrawal syndrome. Timepoint: At the beginning of the study and 12 weeks after intervention. Method of measurement: Withdrawal syndrome questionnaire.