Role of Deep Brain Stimulation on Social Cognition in Parkinsonian Patients

Not Applicable

Completed

• Conditions: Parkinson Disease
• Interventions: Other: Neuropsychological detailed tests with focus on social cognition

• Registration Number: NCT03004573
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system, NMS), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-12-21
• Study First Submitted QC: 2016-12-23
• Study First Posted: 2016-12-29
• Study Start: 2017-03-14
• Primary Completion: 2019-12-13
• Study Completion: 2019-12-13
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-10
• Last Update Posted: 2020-02-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation
• Social insurance

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Exclusion Criteria

• No affiliation to the social insurance
• Patients under guardianship

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Deep brain stimulation	Neuropsychological detailed tests with focus on social cognition	-

Primary Outcome Measures

Name	Time	Method
variation of the emotional recognition score (point lights test) before deep brain surgery	Baseline
variation of the emotional recognition score (point lights test) after deep brain surgery	1 year

Secondary Outcome Measures

Name	Time	Method
PDQ39 score (Parkinson's Disease Questionnaire)	1 year	Quality of Life
MATTIS (dementia rating scale) score	1 year	Global cognition. The Clinical Dementia Rating or CDR is a numeric scale used to quantify the severity of symptoms of dementia

Trial Locations

Locations (1)

Service de Neurologie C Hôpital " Pierre Wertheimer "; 🇫🇷 Bron, France