Functioning of the Mirror Neurons System in Parkinson's Disease and Its Impact on the Social Cognition
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 2
- 主要终点
- variation of the emotional recognition score (point lights test) before deep brain surgery
研究概览
简要总结
Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system, NMS), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation
- •Social insurance
排除标准
- •No affiliation to the social insurance
- •Patients under guardianship
结局指标
主要结局
variation of the emotional recognition score (point lights test) before deep brain surgery
时间窗: Baseline
variation of the emotional recognition score (point lights test) after deep brain surgery
时间窗: 1 year
次要结局
- PDQ39 score (Parkinson's Disease Questionnaire)(1 year)
- MATTIS (dementia rating scale) score(1 year)