Effects of Positive End Expiratory Pressure (PEEP) on Intracranial and Intraocular Pressure in Robot-assisted Laparoscopic Radical Prostatectomy
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- IOP
研究概览
简要总结
To investigate the effects of positive end-expiratory pressure (PEEP) on the intracerebral pressure (ICP) and intraocular pressure (IOP) in patients undergoing robot assisted laparoscopic radical prostatectomy (RALRP)
详细描述
Application of PEEPmay reduce pulmonary complication following RALRP. Meanwhile, it may increase ICP and IOP, which has been debated for decades. Moreover, Trendelenburg position and pneumoperitoneum, which are mandatory for RALRP, may augment elevation of ICP and IOP. This study aims to investigate the effects of PEEP on the ICP and IOP in patients undergoing RALRP.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Patients undergoing robotic-assisted laparoscopic radical prostatectomy
排除标准
- •History of opthalmic disease or surgery
- •History of brain disease or surgery
- •Known ICP elevation
- •Known IOP elevation
- •Presence of lung bullae on chest x-ray
- •History of pneumothorax
结局指标
主要结局
IOP
时间窗: Changes from pre-induction (baseline) at Post-induction 5 min, Pneumoperitoneum insufflation and Trendelenburg position 5 min, Pneumoperitoneum insufflation and Trendelenburg position 30 min, Penumoperitoneum desufflation and supine position 5 min
IOP is directly assessed by measurement of IOP with the Tono-Pen AVIA®
ICP
时间窗: Changes from pre-induction (baseline) at Post-induction 5 min, Pneumoperitoneum insufflation and Trendelenburg position 5 min, Pneumoperitoneum insufflation and Trendelenburg position 30 min, Penumoperitoneum desufflation and supine position 5 min
ICP is indirectly assessed by measurement of optic nerve sheath diameter(ONSD) with the ultrasound
次要结局
未报告次要终点
研究者
Dong Woo Han
Professor
Gangnam Severance Hospital