Cross-Cultural Use of Performance-Based Functional Assessment in Alzheimer's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- University of California San Diego (UCSD) Performance-Based Skills Assessment (UPSA)
研究概览
简要总结
This study plans to assess the effectiveness of performance-based functional assessments (PBFAs) and cognitive assessments in diagnosing Alzheimer's disease in Hispanic/Latino populations. The information from this study will be analyzed with data from the Rocky Mountain Alzheimer's Disease Center Bio-AD study (NCT02612376).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 55 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Persons with age-related MCI or AD according to clinical diagnosis, consistent with National Institute on Aging-Alzheimer's Association (NIA-AA) diagnostic criteria
- •Community-dwelling controls
- •Age > 55 years
- •Have been enrolled and completed at least one visit in the Bio-AD study and consent to access their data (the Rocky Mountain Alzheimer's Disease Center Bio-AD study (clinicaltrials.gov identifier: NCT02612376))
- •Have capacity to provide consent; capacity will be assessed at the time of consent
- •Ability to complete baseline assessments
- •Has informant (study partner) available to complete functional interviews/survey measures
排除标准
- •Presence of concomitant medical, neurological, or psychiatric illness or condition that in the opinion of the investigators would confound interpretation of study results. These include:
- •Korsakoff encephalopathy;
- •active substance abuse;
- •hepatitis C;
- •opportunistic brain infection;
- •brain tumor;
- •active neoplastic disease (skin tumors other than melanoma are not exclusionary; participants with stable prostate cancer may be included at the discretion of the project director);
- •multiple sclerosis;
- •history of clinically significant stroke;
- •current evidence or history in the past 2 years of
- •focal brain lesion,
- •head injury with loss of consciousness in the past year, or
- •DSM-5 criteria for any major psychiatric disorder, including
- •uncontrolled major depression,
- •bipolar disorder,
- •alcohol or substance abuse;
- •deafness or
- •any other disability which may prevent the participant from participating or cooperating in the protocol.
- •Prisoners
- •Any contraindication for MRI
结局指标
主要结局
University of California San Diego (UCSD) Performance-Based Skills Assessment (UPSA)
时间窗: 30 minutes
Measure independent functioning in everyday life for controls and individuals with MCI
Medication Management Ability Assessment
时间窗: 15 minutes
Measure independent management of medications in controls and individuals with MCI
Lawton iADL (instrumental activities of daily living) scale
时间窗: 5 minutes
Measure ability to perform instrumental activities of daily living in controls and individuals with MCI
次要结局
未报告次要终点