Comparison of the analgesic effect of paracetamol and morphine with morphine alone in patients with abdominal pain suspected biliary origi
- Conditions
- Abdominal pains with biliary origin.Pain localized to upper abdomen
- Registration Number
- IRCT201206099984N1
- Lead Sponsor
- Vice chancellor for research, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 90
Aged = 18 and =65 years; Abdominal pain that clinical or Para clinical (evidence of gallbladder or biliary tract stones during the last 12 months) is in favor of biliary origin; NRS = 3. Exclusion criteria: Aged ?18 years and ?65years; Known hypersensitivity to opioids or paracetamol; Unstable vital signs: systolic blood pressure ?90mmHg; Evidence of peritoneal irritation; Pregnancy; Prior to entering the study; Patients with known renal, hepatic or cardiac failure; Patients with transplants (kidney, lung, liver, or heart); Lack of patient consent for participation in the study; Decreased level of consciousness (GCS ?15); Mental retardation; NRS ?3; having received Analgesics during the last 6 hours before presenting to the emergency department; Addiction to opium or methadone use.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The analgesic effect of drugs. Timepoint: Immediately before, 15, 30 minutes after drugs administration. Method of measurement: Pain scores (VAS, NRS).
- Secondary Outcome Measures
Name Time Method Requirement to rescue doses of fentanyl. Timepoint: No significant reduction in pain 30 minutes after drug administration (difference between first and last VAS ?3 mm) and ask for pain medication by the patient at any time during the one hour under the observation. Method of measurement: Clinical examination and asking the patient.;Pruritus, Rash. Timepoint: Within one hour after administration of drugs. Method of measurement: Clinical examination and questionnaire.;Dizziness. Timepoint: Within one hour after administration of drugs. Method of measurement: Clinical examination and questionnaire.;Nausea and vomiting. Timepoint: Within one hour after administration of drugs. Method of measurement: Clinical examination and questionnaire.;Hypotension. Timepoint: Within one hour after administration of drugs. Method of measurement: Clinical examination and questionnaire.