NCT00422253已完成不适用
Will Reduction in Dietary Advanced Glycation End- Products Reduce Chronic Low Grade Inflammation and Improve Insulin Sensitivity in Overweight and Obese Humans
Bayside Health2 个研究点 分布在 1 个国家目标入组 27 人开始时间: 2006年11月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 27
- 试验地点
- 2
研究概览
简要总结
We hypothesize that reduction in dietary advance glycation endproducts (AGE) intake will increase insulin sensitivity and normalise insulin secretion in overweight and obese individuals through reduction of chronic low grade inflammation.
We propose to test this hypothesis by performing euglycemic hypeinsulinemic glucose clamp and intravenous glucose tolerance test before and after low AGE diet and normal Australian diet in a cross-over design. This study will provide information relevant to the development and prevention of type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •weight stable overweight and obese (BMI ≥ 25kg/m2) non-diabetic individuals, aged 18-50 years and healthy according to medical history, blood biochemistry and physical examination.
排除标准
- •Participants will be excluded if they:
- •are aged <18 years or > 50 years;
- •currently smoke, have high alcohol use; or a positive urine drug screening test;
- •have a history of: diabetes, cardiovascular and hematological disease, respiratory, gastrointestinal, endocrine, renal or central nervous system disease, psychosis or psychiatric disorder, active cancer within last 5 years.
- •are actively seeking to lose weight, or if their weight has changed by more than 10 kilograms in the previous 12 months.
- •have been taking medication within one month prior to commencing the study;
- •have acute inflammation (by history, physical or laboratory examination)
- •are on hormonal contraceptives, or pregnant (by HCG urine pregnancy screening test) or lactating
- •have highly unusual dietary habits or follow vegan diets (because of the difficulty in complying with the assigned diet).
- •have current diabetes (determined by history and/or 75g glucose OGTT)
- •are unable to provide informed consent
研究者
研究点 (2)
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