Endoscope CRC cohort: Development and evaluation of diagnostic and prognostic biomarker profiles for colorectal cancer and premalignant lesions

Recruiting

• Conditions: colorectal adenoma; colorectal cancer; 10017990; 10017991

• Registration Number: NL-OMON52029
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 2000

Inclusion Criteria

Adult subjects participating in the Dutch national bowel cancer screening
program with positive iFOBT, with an indication, physical fitness and consent
to undergo a colonoscopy.

Exclusion Criteria

Previous history of colorectal cancer.
History of any malignant disease < 5 years.
Major surgery within 6 months prior to colonoscopy.
Blood transfusion during four weeks prior to blood collection.
Serious non-healing wound, ulcer, or bone fracture.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main parameters are: non-invasive biomarkers in exhaled air, blood<br /><br>plasma/serum, and faeces.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are: patient characteristics, characteristics of the<br /><br>identified pre-malignant and malignant colonic lesions, quality of life, and<br /><br>gastrointestinal symptom scores pre-, during and post-treatment, recurrence<br /><br>rates of CRC, survival rates. </p><br>