StaRTrEc in vascular surgery - Statin-mediated Regulatory T-cell Expansion for protection from cardio-vascular events in vascular surgery patients
Recruiting
- Conditions
- Perioperative cardiovascular events
- Registration Number
- DRKS00023949
- Lead Sponsor
- niversitätsklinikum Essen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 95
Inclusion Criteria
Consent, 18 years or older, planned start of preoperative statin therapy, elective, inpatient vascular surgery within the next 28 days
Exclusion Criteria
Statin therapy within the past 28 days, pregnancy, breastfeeding, contraindication to statin therapy, condition after splenectomy, myocardial infarction, stroke or acute heart failure diagnosed in the past 28 days
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in the number of regulatory T cells circulating in the blood between baseline (before starting statin therapy) and the day of surgery
- Secondary Outcome Measures
Name Time Method Death, cardiovascular death, myocardial ischemia, myocardial infarction, MINS (myocardial injury after non cardiac surgery) ischemic stroke, new heart failure, new atrial fibrillation, length of intensive care stay and length of hospital stay.