Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke Patients
- Conditions
- StrokeSpasticity
- Registration Number
- NCT01817816
- Lead Sponsor
- Changhua Christian Hospital
- Brief Summary
Spasticity, muscle weakness, abnormal gait pattern are co-morbidities commonly seen in stroke patients. They cause disabled condition of patients in activities of daily life and functional performance, and also accidental falls and subsequent fractures.
This study is to evaluate and compare the effects of different phase injection of Botulinum Toxin Type-A at affected limbs on muscle rheological changes, muscle activity, muscle tone, functional performance, gait pattern and energy consumption in stroke patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
- first-ever stroke, with spasticity within 3-months (MAS=2~3)
- independent walking 10 meters (with assistive devices)
- recurrent stroke, cognition impaired
- lower limb fracture
- received anti-spasticity injection in the past
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Change in the muscle tone in upper and lower extremity 4 weeks after injection use modified Ashworth Scale to access elbow, wrist, ankle joint muscle tone 0: normal
1. slight hypertonus, at the end-range 1+: mild hypertonus, catch when limb is moved (\<1/2)
2. moderate hypertonus,, limbs moves easily (\>1/2)
3. passive movement difficult
4. rigid
- Secondary Outcome Measures
Name Time Method Change in the gait pattern as walking 4 weeks after intervention
Trial Locations
- Locations (1)
Changhua Christian Hospital
🇨🇳Taiwan, Changhua, Taiwan
Changhua Christian Hospital🇨🇳Taiwan, Changhua, Taiwan