Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Changhua Christian Hospital
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Change in the muscle tone in upper and lower extremity
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Spasticity, muscle weakness, abnormal gait pattern are co-morbidities commonly seen in stroke patients. They cause disabled condition of patients in activities of daily life and functional performance, and also accidental falls and subsequent fractures.
This study is to evaluate and compare the effects of different phase injection of Botulinum Toxin Type-A at affected limbs on muscle rheological changes, muscle activity, muscle tone, functional performance, gait pattern and energy consumption in stroke patients.
Investigators
Ta-Sen Wei,MD
Director, Physical Medical and Rehabilitation, Principal Investigator, Clinical Professor
Changhua Christian Hospital
Eligibility Criteria
Inclusion Criteria
- •first-ever stroke, with spasticity within 3-months (MAS=2\~3)
- •independent walking 10 meters (with assistive devices)
Exclusion Criteria
- •recurrent stroke, cognition impaired
- •lower limb fracture
- •received anti-spasticity injection in the past
Outcomes
Primary Outcomes
Change in the muscle tone in upper and lower extremity
Time Frame: 4 weeks after injection
use modified Ashworth Scale to access elbow, wrist, ankle joint muscle tone 0: normal 1. slight hypertonus, at the end-range 1+: mild hypertonus, catch when limb is moved (\<1/2) 2. moderate hypertonus,, limbs moves easily (\>1/2) 3. passive movement difficult 4. rigid
Secondary Outcomes
- Change in the gait pattern as walking(4 weeks after intervention)