Specific Preoperative Dynamic Contrast-enhanced MRI Semi-quantitative Markers Can Correlate With Vascularity in Specific Areas of the Glioblastoma Tissue and Predict Recurrence

Completed

• Conditions: Glioblastoma

• Registration Number: NCT04846257
• Lead Sponsor: Egyptian Medical Syndicate

Brief Summary

Radiological Markers of vascularity as wash-in rate, washout rate, and capillary time to peak in different single tumour regions were extracted for all glioblastoma patients before being surgically resected from preoperative DCE-MRI. Tissue samples were obtained from different intratumoral regions and peritumoral oedema and evaluated for the vascular endothelial growth factor (VEGF)

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2021-01-01
• Study Completion: 2021-02-01
• Status Verified: 2021-04
• Study First Submitted: 2021-04-12
• Study First Submitted QC: 2021-04-14
• Last Update Submitted: 2021-04-14
• Study First Posted: 2021-04-15
• Last Update Posted: 2021-04-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 260

Inclusion Criteria

• Patients with newly diagnosed glioblastoma with a maximum diameter from 3-5 cm as a single lesion identified by MRI.
• The lesions should be surgically resected at the time of the presentation.

Exclusion Criteria

N/A

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recurrence of tumor	2018-2021

Trial Locations

Locations (1)

Department of Neurosurgery, Cairo University Faculty of Medicine; 🇪🇬 Cairo, Egypt