Specific Preoperative Dynamic Contrast-enhanced MRI Semi-quantitative Markers Can Correlate With Vascularity in Specific Areas of the Glioblastoma Tissue and Predict Recurrence

Egyptian Medical Syndicate1 site in 1 country260 target enrollmentJanuary 1, 2018

ConditionsGlioblastoma

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Glioblastoma
Sponsor: Egyptian Medical Syndicate
Enrollment: 260
Locations: 1
Primary Endpoint: Recurrence of tumor
Status: Completed
Last Updated: 5 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Radiological Markers of vascularity as wash-in rate, washout rate, and capillary time to peak in different single tumour regions were extracted for all glioblastoma patients before being surgically resected from preoperative DCE-MRI. Tissue samples were obtained from different intratumoral regions and peritumoral oedema and evaluated for the vascular endothelial growth factor (VEGF)

Registry

clinicaltrials.gov

Start Date

January 1, 2018

End Date

February 1, 2021

Last Updated

5 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Egyptian Medical Syndicate

Responsible Party

Principal Investigator

Mohammed A. Azab

Principal Investigator

Cairo University

Eligibility Criteria

Inclusion Criteria

•Patients with newly diagnosed glioblastoma with a maximum diameter from 3-5 cm as a single lesion identified by MRI.
•The lesions should be surgically resected at the time of the presentation.