COMPARATIVE STUDY OF EFFECTIVENESS OF INTRAVENOUS DEXMEDETOMIDINE VERSUS INTRANASAL DEXMEDETOMIDINE FOR ATTENUATION OF HEMODYNAMIC RESPONSES TO LARYNGOSCOPY,INTUBATION AND FIXATION OF SKULL PIN HOLDER IN PATIENTS UNDERGOING CRANIOTOMY: A RANDOMIZED CONTROLLED DOUBLE-BLIND STUDY

King George Mrdical University1 个研究点分布在 1 个国家目标入组 120 人开始时间: 2021年8月30日最近更新: 2021年8月19日

试验速览

阶段: 4 期
状态: 尚未招募
发起方
入组人数: 120
试验地点: 1
主要终点: To compare mean arterial pressure

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study will compare Intravenous dexmedetomidine with intranasal dexmedetomidine for attenuation of hemodynamic response to laryngoscopy, intubation and fixation of skull pin holder in patient undergoing elective craniotomy

研究设计

研究类型: Interventional
分配方式: Computer generated randomization
盲法: Participant, Investigator and Outcome Assessor Blinded

入排标准

年龄范围: 18.00 Year(s) 至 70.00 Year(s)（—）
性别: All

入选标准

•Patient belonging to ASA 1and 2 Patient belongings to age 18 to 70 years Patient giving informed and written consent.

排除标准

•Patient with known allergy or hypersensitivity to dexmedetomidine Patient with history of ischemic heart disease, second or third degree heart block, head injury, uncontrolled hypertension, uncontrolled diabetes, pregnancy,and previous craniotomy incision Patient with respiratory disease and predicted difficult airway Patient who refuse to give consent.

结局指标

主要结局

To compare mean arterial pressure

时间窗: Baseline 5 min after, 10 min after after drug administration before laryngosopy and intubation, at 1 min, 3 min, 5 min after intubation,before pin insertion at 1min, 5 min, 10 min,20 min,30 min,60 min afterpin insertion,sedation status at baseline and 10 min after drug administration

次要结局

To compare systolic and diastolic blood pressure along with sedation score and adverse effects(Baseline 5 min after, 10 min after after drug administration before laryngosopy and intubation, at 1 min, 3 min, 5 min after intubation,before pin insertion at 1min, 5 min, 10 min,20 min,30 min,60 min afterpin insertion,sedation status at baseline and 10 min after drug administration)

研究者

发起方

King George Mrdical University

申办方类型

Other [nil]

研究点 (1)

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