Study comparing intravenous Dexmedetomidine and intravenous Dexmedetomidine for attenuation of hemodynamic responses on laryngoscopy, intubation and skull pin application during open brain surgery

Phase 4

Not yet recruiting

• Conditions: Other disorders of central nervoussystem,

• Registration Number: CTRI/2021/08/035835
• Lead Sponsor: King George Mrdical University

Brief Summary

This study will compare Intravenous dexmedetomidine with intranasal dexmedetomidine for attenuation of hemodynamic response to laryngoscopy, intubation and fixation of skull pin holder in patient undergoing elective craniotomy

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-08-19
• Study Start: 2021-08-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Patient belonging to ASA 1and 2 Patient belongings to age 18 to 70 years Patient giving informed and written consent.

Exclusion Criteria

Patient with known allergy or hypersensitivity to dexmedetomidine Patient with history of ischemic heart disease, second or third degree heart block, head injury, uncontrolled hypertension, uncontrolled diabetes, pregnancy,and previous craniotomy incision Patient with respiratory disease and predicted difficult airway Patient who refuse to give consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare mean arterial pressure	Baseline 5 min after, 10 min after after drug administration before laryngosopy and intubation, at 1 min, 3 min, 5 min after intubation,before pin insertion at 1min, 5 min, 10 min,20 min,30 min,60 min afterpin insertion,sedation status at baseline and 10 min after drug administration

Secondary Outcome Measures

Name	Time	Method
To compare systolic and diastolic blood pressure along with sedation score and adverse effects	Baseline 5 min after, 10 min after after drug administration before laryngosopy and intubation, at 1 min, 3 min, 5 min after intubation,before pin insertion at 1min, 5 min, 10 min,20 min,30 min,60 min afterpin insertion,sedation status at baseline and 10 min after drug administration

Trial Locations

Locations (1)

Kgmu; 🇮🇳 Lucknow, UTTAR PRADESH, India

Kgmu

🇮🇳Lucknow, UTTAR PRADESH, India

Garima

Principal investigator

9956886567

garimasinghetw@gmail.com