Antimicrobial Effect of Calcium Silicate and Pectin as Intracanal Medications in Necrotic Teeth With Periapical Lesions :A Randomized Controlled Clinical Trial
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Microbiome Changes
研究概览
简要总结
It is tackling antimicrobial resistance in endodontics, specifically comparing different intracanal medications used in root canal treatment. Given the growing concern over resistant bacterial strains, our study aims to evaluate the effectiveness of various medicaments in eliminating endodontic pathogens while minimising the risk of resistance development. By integrating microbiological analysis and clinical relevance, our research seeks to provide evidence-based recommendations for optimising intracanal disinfection protocols and improving treatment outcomes in endodontic infections.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients presenting with a single rooted mandibular premolar tooth with a closed apex and a single patent canal type I in Vertucci's classification (Vertucci et al., 1974).
- •Having a necrotic pulp.
- •A pocket depth measurement of < 3 mm.
- •Teeth with no previous history of endodontic treatment.
- •Teeth with periapical lesions of endodontic origin having a periapical index score of 4 or 5 (Orstavik et al., 1986)
- •Patients who took antibiotics within the period of three months before the study.
- •Non-restorable teeth.
- •Teeth with periodontal pockets deeper than 4mm, with or without concomitant or combined endo-perio communication
- •Multirooted teeth.
- •Previously initiated or treated teeth.
- •Teeth with root canal calcifications or resorption.
- •Teeth with internal/external root resorption or root fracture.
- •Immune-compromised patients or patients with systemic diseases i.e. (diabetes mellitus, human immunodeficiency virus, leukemia, neutropenia, undergoing chemo- or systemic corticosteroid therapy)
- •Teeth with root curvature of more than 15 degrees.
- •Pregnant women
- •Patients with known sensitivity to the medicaments used in this study.
排除标准
- 未提供
研究组 & 干预措施
Calcium Hydroxide Intracanal medication
Patients receiving CaOH (Metapaste) intracanal medication
干预措施: Calcium Hydroxide Intracanal medication (Drug)
Calcium silicate based intracanal medication
Patients receiving Calcium silicate based (Bio-C Temp) intracanal medication
干预措施: Calcium silicate based intracanal medication (Drug)
Pectin
Patients receiving Pectin intracanal medication
干预措施: Pectin (Drug)
结局指标
主要结局
Microbiome Changes
时间窗: From enrollment to the end of treatment at 2 weeks
Compare the changes in the microbial composition of the biofilm inside the infected root canal before and after chemo-mechanical preparation and before and after intracanal medicaments application using DNA next-generation sequencing.
次要结局
未报告次要终点
研究者
omar montassir
Assistant Lecturer of Endodontics, Faculty of Dentistry, Suez Canal University
Suez Canal University